PowerPoint 19 Flashcards
how does mercury cross the bbb?
as a methylmercury-cysteine complex
does inorganic mercury cross the bbb easily?
No. As a result, it can stay in brain cells for a long time
What does methylmercury bind to to easily pass across the placenta to the fetus?
red blood cells
What kind of mercury causes motor alterations, cell death, and oxidative stress in the motor cortex of adult rats?
inorganic mercury
What is the purpose of the motor cortex?
- motor cortex is the region of the cerebral cortex
- motor cortex generates neural impulses that control the execution of voluntary movements
what is the brain parenchyma?
tissue that is made of neurons and glial cells
What three things does inorganic mercury lead to on the path to a motor deficit?
- formation of free radicals
- reduction of antioxidant capacity
- lipid peroxidation
What does an increase in calcium in the mitochondria cause?
inbalance and damage of membrane
MeHg prevnts the formation of axons and ______ in growing neurons
dendrites
__________ provide the structural support to the cell as well as involved in cell proliferation, neuronal migrations, and the extension and stabilization of axons
microtubules
MeHg produces ________ changes
epigenetic
Methionine synthase affects DNA methylation, resulting in DNA ___methylation
hypo
in some cases, mercury exposure induces DNA _____methylation
hyper
