Mercury Flashcards

1
Q

What is the only metal that is liquid at room temperature?

A

mercury

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2
Q

how much mercury exposure is needed before causing malformations?

A

ANY exposure to mercury will cause malformations

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3
Q

What does Hg (Hydragyrum) mean?

A

liquid silver

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4
Q

What are some characteristics of transition metals?

A
  • form colored compounds
  • good conductors of heat and electricity
  • malleable
  • less reactive than alkali metals
  • have high melting points EXCEPT mercury
  • have a wide range of oxidation states resulting in different ionic forms
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5
Q

What are some transition metal examples?

A
  • iron
  • manganese
  • chromium
  • copper
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6
Q

What is significant about the fact that mercury is liquid at room temperature?

A

that means it evaporates at room temperature

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7
Q

what are the naturally occurring forms of mercury?

A
  • elemental or metallic mercury
  • inorganic mercury
  • organic mercury
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8
Q

True or false:

Mercury can touch the BBB

A

False, mercury itself cannot cross or touch the BBB

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9
Q

What is the pathway from inorganic mercury to methylmercury in humans?

A
  1. Discharge
  2. Biomethylation
  3. Bioaccumulation
  4. Exposure
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10
Q

What is the most frequently encountered form of mercury?

A

methylmercury

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11
Q

True or false:

All forms of mercury are toxic

A

True!

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12
Q

What are some of the environmental sources of mercury?

A
  • natural degassing of earth (like volcanoes)
  • combustion of fossil fuel
  • incineration
  • industrial discharges and wastes
  • dental amalgams
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13
Q

What four disorders are caused by mercury exposure?

A
  • Minamata Disease
  • Learning and Memory, Neuro-psychiatric disorders, sensory deficits
  • Neurodegenerative diseases (alzheimer’s)
  • Autism
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14
Q

What are dental amalgams made of?

A

about half liquid mercury and about half powder containing silver, tin, copper, and other metals

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15
Q

What are the factors that determine the health effects of mercury?

A
  • the type of mercury
  • the dose
  • the age or developmental stage
  • the duration of exposure
  • the route of exposure
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16
Q

What are neural stem cells?

A

self-renewing cells that differentiate into neurons, glial cells,astrocytes, and oligodendrocytes

17
Q

A mouse brain that was exposed to what lead to Induced apoptosis?

A

methylmercury

18
Q

action mediated through ________ signaling in mercury exposure

A

Notch

19
Q

What does Notch prevent?

A

it prevents the NSCs from differentiating

20
Q

__________________ acts through stimulation of Notch to inhibit neuronal differentiation

A

methylmercury

21
Q

Additional effects of methylmercury include?

A
  • impaired mitochondrial function
  • Generation of reactive oxygen species (ROS)
  • alteration of intracellular calcium ion homeostasis
22
Q
A