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Virology 2 > Questions from S 16 > Flashcards

Questions from S 16 Flashcards

1
Q

Resistance mutation below

What is the virus?

Which drug does it confer resistance to?

H275Y

A

Influenza A H1

Oseltamavir

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2
Q

Resistance mutation below

What is the virus?

Which drug does it confer resistance to?

M184V

A

HIV-1
Reverse transcriptase

Lamivudine
Emtricitabine

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3
Q

Resistance mutation below

What is the virus?

Which drug does it confer resistance to?

L180M

A

HBV

Lamivudine
Emtricitabine

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4
Q

Resistance mutation below

What is the virus?

Which drug does it confer resistance to?

M204V
M204I

A

HBV

Lamivudine
Emtricitabine

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5
Q

Resistance mutation below

What is the virus?

Which drug does it confer resistance to?

N236T

A

HBV

Tenofovir

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6
Q

Resistance mutation below

What is the virus?

Which drug does it confer resistance to?

I161 I/T
T184L

A

HBV

Entecavir

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7
Q

Resistance mutation below

What is the virus?

Which drug does it confer resistance to?

T409M
M460V

A

CMV

T409M (codes for UL97) – Maribavir
M460V (codes for UL97) – Ganciclovir

Any mutation >400 is likely to be CMV as long genome

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8
Q

What is the dose of foscarnet?

A

Adult

HSV
40mg/kg TDS for 3 weeks

CMV
60mg/kg TDS for 3 weeks

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9
Q

What is the dose of cidofovir?

A

Initially 5 mg/kg once weekly for 2 weeks

then maintenance 5 mg/kg every 2 weeks

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10
Q

What are the adult and neonatal aciclovir doses for encephalitis?

A

Adults immunocompetent:
10mg/kg TDS for encephalitis 14 days with repeat LP

Adults immunocompromised:
10mg/kg TDS for encephalitis 21 days with repeat LP

Aged 3 months to 12 years:
10mg/kg TDS for encephalitis 21 days with repeat LP

Neonate:
20mg/kg for encepahlitis
21 days

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11
Q

Aciclovir drug resistance

Which genes are common mutations?

A

UL5 - Helicase primase

UL23 - thymidine kinase
TKneg
TKpartial
TKaltered

UL30 - DNA polymerase

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12
Q

What is the most important blood test for someone on Tenofovir disoproxil fumarate?

A

Bone profile
Renal function

Hypophosphatemia would recommend switch to Tenfovir alafenamide

l

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13
Q

In which cases would you recommend switching from Tenofovir disoproxil fumarate to Tenofovir alafenamide?

A

Renal dysfunction

Hypophosphataemia

<25 years old who have not reached peak bone mass
>65 with risk of osteoporosis

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14
Q

Neonate treated for encephalitis with IV aciclovir 20mg/kg TDS

What do you do when stopping treatment?

A

Repeat LP - if negative, stop treatment

suppressive aciclovir for 12 months, to prevent a reactivation - improved neurological outcomes

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Virology 2 (57 decks)

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