Qualitative Disorders of Platelets and Vasculature

Question 1

1. The clinical presentation of platelet-related bleeding may
   include all of the following except:
   a. Bruising
   b. Nosebleeds
   c. Gastrointestinal bleeding
   d. Bleeding into the joints (hemarthroses)

Answer 1

d. Bleeding into the joints (hemarthroses)

Question 2

2. A defect in GP IIb/IIIa causes:
   a. Glanzmann thrombasthenia
   b. Bernard-Soulier syndrome
   c. Gray platelet syndrome
   d. Storage pool disease

Answer 2

a. Glanzmann thrombasthenia

Question 3

3. Aspirin ingestion blocks the synthesis of:
   a. Thromboxane A2
   b. Ionized calcium
   c. Collagen
   d. ADP

Answer 3

a. Thromboxane A2

Question 4

4. Patients with Bernard-Soulier syndrome have which of the
   following laboratory test findings?
   a. Abnormal platelet response to arachidonic acid
   b. Abnormal platelet response to ristocetin
   c. Abnormal platelet response to collagen
   d. Thrombocytosis

Answer 4

b. Abnormal platelet response to ristocetin

Question 5

5. Which of the following is the most common of the hereditary platelet function defects?
   a. Glanzmann thrombasthenia
   b. Bernard-Soulier syndrome
   c. Storage pool defects
   d. Multiple myeloma

Answer 5

c. Storage pool defects

Question 6

6. A mechanism of antiplatelet drugs targeting GP IIb/IIIa
   function is:
   a. Interference with platelet adhesion to the subendothelium by blocking of the collagen binding site
   b. Inhibition of transcription of the GP IIb/IIIa gene
   c. Direct binding to GP IIb/IIIa
   d. Interference with platelet secretion

Answer 6

c. Direct binding to GP IIb/IIIa

Question 7

7. The impaired platelet function in myeloproliferative neoplasms results from:
   a. Abnormally shaped platelets
   b. Extended platelet life span
   c. Increased procoagulant activity
   d. Decreased numbers of a- and dense granules

Answer 7

d. Decreased numbers of a- and dense granules

Question 8

8. Which is a congenital qualitative platelet disorder?
   a. Senile purpura
   b. Ehlers-Danlos syndrome
   c. Henoch-Schönlein purpura
   d. Waldenström macroglobulinemia

Answer 8

b. Ehlers-Danlos syndrome

Question 9

9. In uremia, platelet function is impaired by higher than normal levels of:
   a. Urea
   b. Uric acid
   c. Creatinine
   d. NO

Answer 9

d. NO

Question 10

10. The platelet defect associated with increased paraproteins is:
    a. Impaired membrane activation owing to protein coating
    b. Hypercoagulability owing to antibody binding and
    membrane activation
    c. Impaired aggregation because the hyperviscous plasma
    prevents platelet-endothelium interaction
    d. Hypercoagulability because the increased proteins bring
    platelets closer together, which leads to inappropriate
    aggregation

Answer 10

a. Impaired membrane activation owing to protein coating