Hemorrhagic Disorders and Laboratory Assessment

Question 1

1. What is the most common acquired bleeding disorder?
   a. Vitamin K deficiency
   b. Liver disease
   c. ACOTS
   d. VWD

Answer 1

c. ACOTS

Question 2

2. Which is a typical form of anatomic bleeding?
   a. Epistaxis
   b. Menorrhagia
   c. Hematemesis
   d. Soft tissue bleed

Answer 2

d. Soft tissue bleed

Question 3

3. What factor deficiency has the speediest effect on the prothrombin time?
   a. Prothrombin deficiency
   b. Factor VII deficiency
   c. Factor VIII deficiency
   d. Factor IX deficiency

Answer 3

b. Factor VII deficiency

Question 4

4. Which of the following conditions causes a prolonged
   thrombin time?
   a. Antithrombin deficiency
   b. Prothrombin deficiency
   c. Hypofibrinogenemia
   d. Warfarin therapy

Answer 4

c. Hypofibrinogenemia

Question 5

5. In what subtype of VWD is the RIPA test result positive
   when ristocetin is used at a concentration of less than
   0.5 mg/mL?
   a. Subtype 2A
   b. Subtype 2B
   c. Subtype 2N
   d. Type 3

Answer 5

b. Subtype 2B

Question 6

6. What is the typical treatment for vitamin K deficiency when
   the patient is bleeding?
   a. Vitamin K and PCC
   b. Vitamin K and plasma
   c. Vitamin K and platelet concentrate
   d. Vitamin K and factor VIII concentrate

Answer 6

b. Vitamin K and plasma

Question 7

7. If a patient has anatomic soft tissue bleeding and poor
   wound healing, but the PT, PTT, thrombin time, platelet
   count, and platelet functional assay results are normal,
   what factor deficiency is indicated?
   a. Fibrinogen
   b. Prothrombin
   c. Factor XII
   d. Factor XIII

Answer 7

d. Factor XIII

Question 8

8. What therapy may be used for a hemophilic boy who is
   bleeding and who has a high titer of factor VIII inhibitor?
   a. rFVIIa
   b. Plasma
   c. Cryoprecipitate
   d. Factor VIII concentrate

Answer 8

a. rFVIIa

Question 9

9. What is the most prevalent form of VWD?
   a. Type 1
   b. Type 2A
   c. Type 2B
   d. Type 3

Answer 9

a. Type 1

Question 10

10. Which of the following assays is used to distinguish vitamin K deficiency from liver disease?
    a. PT
    b. Protein C assay
    c. Factor V assay
    d. Factor VII assay

Answer 10

c. Factor V assay

Question 11

11. Mucocutaneous hemorrhage is typical of:
    a. Acquired hemorrhagic disorders
    b. Localized hemorrhagic disorders
    c. Defects in primary hemostasis
    d. Defects in fibrinolysis

Answer 11

c. Defects in primary hemostasi