Mature Lymphoid Neoplasms

Question 1

1. In most cases, the diagnosis of lymphoma relies on all of
   the following except:
   a. Microscopic examination of affected lymph nodes
   b. Immunophenotyping using immunohistochemistry or
   flow cytometry
   c. Molecular or cytogenetic analysis
   d. Peripheral blood examination and a complete blood
   count

Answer 1

d. Peripheral blood examination and a complete blood
count

Question 2

2. The most common lymphoma occurring in young adults is:
   a. Follicular lymphoma
   b. DLBCL
   c. Hodgkin lymphoma
   d. Mycosis fungoides

Answer 2

c. Hodgkin lymphoma

Question 3

3. In a normal lymph node, the medulla includes predominantly:
   a. T cells
   b. B cells
   c. Tingible-body macrophages
   d. Plasma cells

Answer 3

d. Plasma cells

Question 4

4. The t(11;14) is the defining feature of:
   a. Follicular lymphoma
   b. Hodgkin lymphoma
   c. CLL
   d. Mantle cell lymphoma

Answer 4

d. Mantle cell lymphoma

Question 5

5. The immunophenotype of mycosis fungoides is:
   a. The normal T cell immunophenotype
   b. An abnormal T cell immunophenotype with expression
   of CD4 and loss of CD7 antigen
   c. A mix of CD41 and CD81 T cells
   d. An abnormal T cell immunophenotype with expression
   of CD8 and loss of CD7 antigen

Answer 5

b. An abnormal T cell immunophenotype with expression
of CD4 and loss of CD7 antigen

Question 6

6. What is the major morphologic difference between Hodgkin lymphoma and other B cell lymphomas?
   a. The extent of the lymph node involvement
   b. The presence of numerous reactive lymphocytes and
   only a few malignant cells in Hodgkin lymphoma
   c. The presence of numerous tingible-body macrophages in
   Hodgkin lymphoma
   d. The preservation of normal lymph node architecture in
   Hodgkin lymphoma

Answer 6

b. The presence of numerous reactive lymphocytes and
only a few malignant cells in Hodgkin lymphoma

Question 7

7. Which morphologic diagnosis has to be confirmed with
   molecular studies demonstrating the presence of t(8;14)?
   a. Mantle cell lymphoma
   b. Burkitt lymphoma
   c. Follicular lymphoma
   d. Sézary syndrome

Answer 7

b. Burkitt lymphoma

Question 8

8. What is the function of the germinal center?
   a. Generation of B cells producing immunoglobulins with
   the highest affinity for a particular antigen through the
   process of somatic mutation
   b. Production of plasma cells that secrete specific immunoglobulins following antigenic stimulation
   c. T cell maturation following T cell education in the thymus
   d. Generation of dendritic cells with unique antigen-processing
   capabilities

Answer 8

a. Generation of B cells producing immunoglobulins with
the highest affinity for a particular antigen through the
process of somatic mutation

Question 9

9. Marked paracortical expansion is most commonly seen in:
   a. Rheumatoid arthritis
   b. Syphilis
   c. Dermatopathic lymphadenopathy
   d. Follicular lymphoma

Answer 9

c. Dermatopathic lymphadenopathy

Question 10

10. MGUS is best described as:
    a. The presence of monoclonal immunoglobulin in serum
    with only mild bone marrow plasmacytosis
    b. The presence of monoclonal serum or urine immunoglobulin with significant bone marrow plasmacytosis
    c. The presence of significant bone marrow plasmacytosis
    in a patient with only a few clinical symptoms of
    plasma cell myeloma
    d. The presence of monoclonal immunoglobulin in a patient with a solitary mass composed of plasma cells

Answer 10

a. The presence of monoclonal immunoglobulin in serum
with only mild bone marrow plasmacytosis