Normal Hemostasis and Coagulation

Question 1

1. What intimal cell synthesizes and stores VWF?
   a. Smooth muscle cell
   b. Endothelial cell
   c. Fibroblast
   d. Platelet

Answer 1

b. Endothelial cell

Question 2

2. What subendothelial structural protein triggers coagulation
   through activation of factor VII?
   a. Thrombomodulin
   b. Nitric oxide
   c. Tissue factor
   d. Thrombin

Answer 2

c. Tissue factor

Question 3

3. What coagulation plasma protein should be assayed when
   platelets fail to aggregate properly?
   a. Factor VIII
   b. Fibrinogen
   c. Thrombin
   d. Factor X

Answer 3

b. Fibrinogen

Question 4

4. What role does vitamin K play for the prothrombin group
   factors?
   a. Provides a surface on which the proteolytic reactions of
   the factors occur
   b. Protects them from inappropriate activation by compounds such as thrombin
   c. Accelerates the binding of the serine proteases and their
   cofactors
   d. Carboxylates the factors to allow calcium binding

Answer 4

d. Carboxylates the factors to allow calcium binding

Question 5

5. What is the source of fibrinopeptides A and B?
   a. Plasmin proteolysis of fibrin polymer
   b. Thrombin proteolysis of fibrinogen
   c. Proteolysis of prothrombin by factor Xa
   d. Plasmin proteolysis of cross-linked fibrin

Answer 5

b. Thrombin proteolysis of fibrinogen

Question 6

6. What serine protease forms a complex with factor VIIIa, and
   what is the substrate of this complex?
   a. Factor VIIa, factor X
   b. Factor Va, prothrombin
   c. Factor Xa, prothrombin
   d. Factor IXa, factor X

Answer 6

d. Factor IXa, factor X

Question 7

7. What protein secreted by endothelial cells activates fibrinolysis?
   a. Plasminogen
   b. TPA
   c. PAI-1
   d. TAFI

Answer 7

b. TPA

Question 8

8. What two regulatory proteins form a complex that digests
   activated factors V and VIII?
   a. TFPI and Xa
   b. Antithrombin and protein C
   c. APC and protein S
   d. Thrombomodulin and plasmin

Answer 8

c. APC and protein S

Question 9

9. Coagulation factor VIII circulates bound to:
   a. VWF
   b. Factor IX
   c. Platelets
   d. Factor V

Answer 9

a. VWF

Question 10

10. Most coagulation factors are synthesized in:
    a. The liver
    b. Monocytes
    c. Endothelial cells
    d. Megakaryocytes

Answer 10

a. The liver