Laboratory Evaluation of Hemostasis Flashcards

1
Q
  1. What happens if a coagulation specimen collection tube is
    underfilled?
    a. The specimen clots and is useless
    b. The specimen is hemolyzed and is useless
    c. Clot-based test results are falsely prolonged
    d. Chromogenic test results are falsely decreased
A

c. Clot-based test results are falsely prolonged

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2
Q
  1. If you collect blood into a series of tubes, when in the sequence should the hemostasis (blue stopper) tube be filled?
    a. After a lavender-topped or green-topped tube
    b. First, or after a nonadditive tube
    c. After a serum separator tube
    d. Last
A

b. First, or after a nonadditive tube

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3
Q
  1. What is the effect of hemolysis on a hemostasis specimen?
    a. In vitro platelet and coagulation activation occur
    b. The specimen is icteric or lipemic
    c. Hemolysis has no effect
    d. The specimen is clotted
A

a. In vitro platelet and coagulation activation occur

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4
Q
  1. Most coagulation testing must be performed on PPP, which
    is plasma with a platelet count less than:
    a. 1000/uL
    b. 10,000/uL
    c. 100,000/uL
    d. 1,000,000/uL
A

b. 10,000/uL

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5
Q
  1. You wish to obtain a 5-mL specimen of whole-blood/
    anticoagulant mixture. The patient’s hematocrit is 65%.
    What volume of anticoagulant should you use?
    a. 0.32 mL
    b. 0.5 mL
    c. 0.64 mL
    d. 0.68 mL
A

a. 0.32 mL

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6
Q
  1. You perform whole-blood lumiaggregometry on a specimen from a patient who complains of easy bruising.
    Aggregation and secretion are diminished when the agonists, thrombin, ADP, arachidonic acid, and collagen are
    used. What is the most likely platelet abnormality?
    a. Storage pool disorder
    b. Aspirin-like syndrome
    c. ADP receptor anomaly
    d. Glanzmann thrombasthenia
A

a. Storage pool disorder

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7
Q
  1. What is the reference assay for HIT?
    a. Enzyme immunoassay
    b. Serotonin release assay
    c. Platelet lumiaggregometry
    d. Washed platelet aggregation
A

b. Serotonin release assay

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8
Q
  1. What agonist is used in platelet aggregometry to detect VWD?
    a. Arachidonic acid
    b. Ristocetin
    c. Collagen
    d. ADP
A

b. Ristocetin

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9
Q
  1. Deficiency of which single factor is likely when the PT result is prolonged and the PTT result is normal?
    a. Factor V
    b. Factor VII
    c. Factor VIII
    d. Prothrombin
A

b. Factor VII

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10
Q
  1. A prolonged PT, a low factor VII level, but a normal factor
    V level are characteristic of an acquired coagulopathy associated with which of the following?
    a. Hemophilia
    b. Liver disease
    c. Thrombocytopenia
    d. Vitamin K deficiency
A

d. Vitamin K deficiency

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11
Q
  1. The patient has deep vein thrombosis. The PTT is prolonged and is not corrected in an immediate mix of patient
    plasma with an equal part of normal plasma. What is the
    presumed condition?
    a. Factor VIII inhibitor
    b. Lupus anticoagulant
    c. Factor VIII deficiency
    d. Factor V Leiden mutation
A

b. Lupus anticoagulant

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12
Q
  1. What condition causes the most pronounced elevation in
    the result of the quantitative D-dimer assay?
    a. Deep vein thrombosis
    b. Fibrinogen deficiency
    c. Paraproteinemia
    d. DIC
A

d. DIC

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13
Q
  1. What is the name given to the type of assay that uses a
    synthetic polypeptide substrate that releases a chromophore on digestion by its serine protease?
    a. Clot-based assay
    b. Molecular diagnostic assay
    c. Fluorescence immunoassay
    d. Chromogenic substrate assay
A

d. Chromogenic substrate assay

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14
Q
  1. What component of the fibrinolytic process binds and
    neutralizes free plasmin?
    a. PAI-1
    b. TPA
    c. a2-Antiplasmin
    d. Urokinase
A

c. a2-Antiplasmin

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