Leukocyte Development, Kinetics, and Functions

Question 1

1. Neutrophils and monocytes are direct descendants of a
   common progenitor known as:
   a. CLP
   b. GMP
   c. MEP
   d. HSC

Answer 1

b. GMP

Question 2

2. The stage in neutrophilic development in which the nucleus
   is indented in a kidney bean shape and the cytoplasm has
   secondary granules that are lavender in color is the:
   a. Band
   b. Myelocyte
   c. Promyelocyte
   d. Metamyelocyte

Answer 2

d. Metamyelocyte

Question 3

3. Type II myeloblasts are characterized by:
   a. Presence of fewer than 20 primary granules per cell
   b. Basophilic cytoplasm with many secondary granules
   c. Absence of granules
   d. Presence of a folded nucleus

Answer 3

a. Presence of fewer than 20 primary granules per cell

Question 4

4. Which one of the following is a function of neutrophils?
   a. Presentation of antigen to T and B lymphocytes
   b. Protection against reexposure by same antigen
   c. Nonspecific destruction of foreign organisms
   d. Initiation of delayed hypersensitivity response

Answer 4

c. Nonspecific destruction of foreign organisms

Question 5

5. Which of the following cells are important in immune regulation, allergic inflammation, and destruction of tissue
   invading helminths?
   a. Neutrophils and monocytes
   b. Eosinophils and basophils
   c. T and B lymphocytes
   d. Macrophages and dendritic cells

Answer 5

b. Eosinophils and basophils

Question 6

6. Basophils and mast cells have high-affinity surface receptors for which immunoglobulin?
   a. A
   b. D
   c. E
   d. G

Answer 6

c. E

Question 7

7. Which of the following cell types is capable of differentiating into osteoclasts, macrophages, or dendritic cells?
   a. Neutrophils
   b. Lymphocytes
   c. Monocytes
   d. Eosinophils

Answer 7

c. Monocytes

Question 8

8. Macrophages aid in adaptive immunity by:
   a. Degrading antigen and presenting it to lymphocytes
   b. Ingesting and digesting organisms that neutrophils
   cannot
   c. Synthesizing complement components
   d. Storing iron from senescent red cells

Answer 8

a. Degrading antigen and presenting it to lymphocytes

Question 9

9. Which of the following is the final stage of B cell maturation after activation by antigen?
   a. Large, granular lymphocyte
   b. Plasma cell
   c. Reactive lymphocyte
   d. Immunoblast

Answer 9

b. Plasma cell

Question 10

10. The following is unique to both B and T lymphocytes and
    occurs during their early development:
    a. Expression of surface antigens CD4 and CD8
    b. Maturation in the thymus
    c. Synthesis of immunoglobulins
    d. Rearrangement of antigen receptor genes

Answer 10

d. Rearrangement of antigen receptor genes