Q2 URINARY and EXOTICS Flashcards
how much function does the kidney have to lose to go into renal failure?
75-80%
what is the most important cause of acute renal failure
tubular necrosis
mechanisms for non-renal lesions of uremia
endothelial damage, ammonia production, Ca/P imbalance
what is the pathogenesis of secondary hyperparathyroidism in renal failure
insufficient renal function, high P, high PTH, Ca removed from bones, causes fibrous osteodystrophy
polycystic kidney disease common breeds and where else are cysts found
persian cats and bull terriers, cysts often also in pancreas and liver
ectopic ureters breed predilection and clinical sign
huskies with urinary incontinence
urachal anomalies
patent urachus (male foals drip urine), persistent urachal remnant (incomplete emptying of bladder)
CHV-1 pathogenesis
young puppies with intrauterine infection leads to renal vascular insult, with eosinophilic inclusion bodies in epithelium
gross differences in acute, subacute and chronic renal infarcts
red and swollen, white with peripheral red area, white and depressed
analgesic nephropathy
NSAID administration and dehydration leads to hypoxia of renal papillae
three parts of the glomerular filtration barrier
capillary endothelium, basement membrane, and podocytes
what are the four components to nephrotic syndrome
proteinuria, hypoalbuminemia, generalized edema, hypercholesterolemia
glomerular nephritis pathology
immune complex formation lodges in glomeruli, inflammatory reaction of mesangial cells (bernies)
what breeds are predisposed to renal amyloidosis
shar pei, abyssinian
what are the most common bacteria implicated for bacterial embolic nephritis in horses, SR, pigs and cattle
horse: actinobacillus equuli
SR: corynebacterium pseudotuberculosis
pigs: erysipelothrix rhusiopathiae
cattle: trueperella pyogenes
ethylene glycol pathogenesis
rapidly absorbed and metabolized, calcium oxalate crystals
melamine and cyanuric acid toxicity
necrosis of the DISTAL convoluted tubules with golden crystals
how does oak cause disease in large animals
tannin metabolites target endothelial cells causing hematuria (cortical petechiae)
worst aminoglycoside and how do they become toxic to the kidneys
neomycin and accumulates in lysosomes of proximal convoluted tubules
hemoglobinuria causes in sheep and horses
sheep: copper tox, blood transfusion
horse: red maple toxicity and neonatal isoerythrolysis (GUN METAL)
common bacteria involved in ascending infection in all animals, cattle, and pigs
e coli, corynebacterium renale and trueperella, and actinobaculum suis
where does lepto like to hang out after a week
proximal convoluted tubules
swine renal parasite that migrates through the liver
stephanurus dentatus
giant kidney worm that infects any fish eating mammal
dioctophyma renale
pearsonema
subclinical renal parasite
most common primary renal tumor of dog
renal carcinoma, often mets (cattle benign but bilateral)