Pyridostygmine Flashcards
1
Q
class
A
reversal; anticholinesterase
2
Q
structure
A
quaternary ammonia
does not cross BBB
3
Q
mech of action
A
covalently binds to the carbamyl group of the acetylcholinesterases, inhibiting the breakdown of ACh in the NMJ and increasing the availability of ACh at the motor end plate
4
Q
LS
Vd
A
LS: low
Vd: 1 L/kg
5
Q
active metabolite
A
none
6
Q
elimination
A
70-90% excreted by kidneys;
25% metabolized by hepatic microsomal enzyme system
7
Q
side effects
A
decreased SVR, BP, HR
bronchoconstriction
increased saliva, gastric secretions
8
Q
contraindications
A
renal failure with increased doa
GI/GU obstruction
asthma
use with caution in CAD
9
Q
onset
DOA
T1/2
A
onset: 16 min
DOA: 75 min
T1/2: 112 min
10
Q
dose
A
100-300 mcg/kg
administer with glyco 0.01 mg/kg
PO 60 mg
