Flumazenil Flashcards
1
Q
Brand name
A
Romazicon
2
Q
class
A
benzo antagonist/reversal
3
Q
Structure
A
imadazobenzodiazepam derivative
4
Q
Mech of Action
A
Competes with benzos for binding sites on GABA-A receptor, reversing their effect. high affinity for receptor
5
Q
pharmacokinetics
PB
Vd
elimination
A
Pb - 50%
Vd - 0.5 L/Kg
elimination - metabolized by liver and excreted by urine
6
Q
Onset
DOA
T1/2
A
onset - 1-2 min
DOA - 30-60 min
T1/2 - 1 hr
7
Q
active metabolite
A
none
8
Q
side effects
A
dizzy, sweating, agitation
depression, confusion, abnormal vision
N/V
9
Q
contraindications
A
DO NOT USE in seizure disorder
hypersensitivity
10
Q
other
A
given to reverse respiratory depression and cardiac effects
11
Q
dose
A
0.2 mg IV, wait 2 min then repeat 0.1 mg q 60 sec to max of 3 mg
