Etomidate Flashcards
1
Q
class
A
non-barbiturate induction agent
2
Q
structure
A
carboxylated imadazole derivative
3
Q
mech of action
A
mimics GABA at GABA-A receptors AND increases affinity for GABA to GABA-A receptors. increases Cl- conduction, hyperpolarizes cell, resists depolarization
4
Q
pharmacokinetics
PB
LS
Vd
A
PB: 75%
lipid soluble at physiologic pH
Vd: 2.5-4.5 L/kg
5
Q
elimination
A
liver hydrolysis by CYP450 and metabolized by plasma esterases
excreted in urine/bile
hepatic blood flow alters clearance
6
Q
onset
doa
T1/2
A
onset: 1 min
doa: ??
T1/2: 3-5 hrs
7
Q
side effects
A
decreases CBF, CMRO2, ICP anticonvulsant, BUT can cause seizures in pts with hx CARDIAC STABLE enhances NMB 30-40% N/V myoclonus hiccups adrenocorticoid suppression for 4-8 hrs
8
Q
contraindications
A
seizures, porphyria, addision’s disease
9
Q
dose
A
induction: 0.2-0.6 mg/kg IV
sedation: 5-8 mcg/kg/min
maintenance: 10 mcg/kg/min
10
Q
active metabolite
A
none
