Neostigmine Flashcards
1
Q
Class
A
reversal, anticholinesterase
2
Q
structure
A
quanternary ammonia
does not cross bbb
3
Q
mech of action
A
covalently binds to the carbamyl group of the acetylcholinesterases, inhibiting the breakdown of AcH in the NMJ and increases the availability of ACh at the motor end plate
4
Q
PB
LS
VD
A
PB low
LS low
VD: 1L/kg
5
Q
elimination
A
plasma and liver esterases and excreted 50% unchanged in urine
6
Q
active metabolite
A
3-hydroxyphenyltrimethylammonium
1/10th as potent
7
Q
side effects
A
decrease SVR, BP, HR
bronchoconstriction
increase saliva
increase gastric secretion
seizures
8
Q
contraindications
A
renal failure: increased doa
GI/GU obstruction
asthma
use with caution in CAD
9
Q
dose
A
0.04 - 0.07 mg/kg
administrate with glyco 0.01 mg/kg
10
Q
onset
DOA
T1/2
A
onset: 3-5 min
DOA: 1 hr
T1/2: 70-80 min
