Dexmedetomidine Flashcards
1
Q
class
A
non-barbiturate induction agent
2
Q
structure
A
imadazole derivative
3
Q
mech of action
A
alpha 2 agonist - decreases NE release presynaptically causing sedation, anxiolysis, analgesia
produces hypnosis in the locus cerelus
4
Q
pharacokinetics PB LS Vd elimination
A
PB 90%
low lipid solubility
Vd: 3L/kg
elimination: conjugated in liver, excreted in urine/bile
5
Q
onset
doa
T1/2
A
onset: rapid, distributes in 6 minutes
doa: 5-8 min
T1/2: 2-3 hrs
6
Q
active metabolite
A
none
7
Q
side effects
A
decrease CBF
NO CHANGE to CMRO2 & ICP
decrease SVR, BP, HR, SNS response
small decrease TV, minimal change RR
potentiates effects of opioids
decreases thermoregulation
8
Q
contraindications
A
afib, HB, severe brady, hypotension
9
Q
other
A
can build tolerance
mimics sleep
inhibits CYP450
10
Q
dose
A
1 mcg/kg over 15 min bolus, then 0.2-1 mcg/kg/hr
