Lorazepam Flashcards
1
Q
Class
A
Benzo
2
Q
Structure
A
Benzene ring fused w/ 7 member diazepine ring
3
Q
mech of action
A
potentiates binding of GABA to the GABA-A receptor, keeping the Cl- channels open and hyperpolarizing the cell, making it resistant to excitation
4
Q
pharmacokinetics PB LS Vd Elimination
A
80% PB
highly LS
0.8-1.3 L/Kg Vd
elimination - CYP450 and excreted in urine
5
Q
Onset
DOA
T1/2
A
onset 20-30 min
DOA -
T1/2 - 10-20 hrs
6
Q
Active metabolite
A
none
7
Q
Side effects
A
decrease CBF, CMRO2 no isoelectric eeg preserves CO2 response DOES NOT flatten CO2 curve does not attenuate response to DVL neuroprotective can cause paradoxical excitation decrease SVR, BP, CO with induction dose
decrease RR and TV with opioids
8
Q
Contraindications
A
decrease dose with hepatic/renal patients
caution with elderly
synergistic with opioids
DO NOT give with glaucoma
9
Q
Other
A
most potent benzo
pain on injection (propylene glycol)
does not effect NMB
10
Q
dose
A
pre-med: 1-4 mg IV; 50 mcg/kg PO
