Endrophonium Flashcards
1
Q
class
A
reversal; anticholinesterase
2
Q
structure
A
quanternary ammonium
does not cross BBB
3
Q
mech of action
A
reversible H+ binding to the acetylcholinesterases forming an electrostatic attachment and increase the amt of ACh at the NMJ
4
Q
LS
Vd
A
LS: low
Vd: 1 L/kg
5
Q
onset
doa
T1/2
A
onset: rapid, peak 1-2 min
doa: 30-60 min
T1/2: 110 min
6
Q
elimination
A
75% excreted by kidneys unchanged
25% hepatic metabolism
7
Q
side effects
A
decreased SVR, BP, HR
bronchoconstriction
increased saliva, gastric secretions
8
Q
active metabolite
A
none
9
Q
dose
A
0.5-1 mg/kg
administer with atropine 0.01 mg/kg
10
Q
contraindications
A
renal failure will increase doa
GI/GU obstruction
asthma
use with caution in CAD
