Propofol

Question 1

class

Answer 1

non-barbiturate induction agent

Question 2

structure

Answer 2

2,6 di-isopropophenol

Question 3

mech of action

Answer 3

discourages dissociation of GABA from GABA-A receptor, increasing Cl- conduction, hyperpolarizes cell, resists depolarization
inhibits glutamate at the NMDA receptor

Question 4

pharmacokinetics
PB
LS
Vd

Answer 4

highly PB
lipid soluble
Vd: 3.5-4.5 L/kg

Question 5

elimination

Answer 5

metabolized by CYP450, excreted in urine

clearance faster than HBF, extrahepatic metabolism

Question 6

onset
doa
T1/2

Answer 6

onset: 30 sec
doa: 2-8 min
T1/2 0.5-1.5 hr

Question 7

active metabolite

Answer 7

none

Question 8

side effects

Answer 8

decreases CBF, CMRO2, ICP
isoelectric EEG

severe drop in SVR, BP
NO CHANGE to HR

dose dependent decreased RR, TV
bronchodilation
myoclonus

Question 9

contraindications

Answer 9

soy, egg allergy
hypovolemia
caution with elderly

Question 10

other

Answer 10

burning on injection
anti-emetic at low dose
generic propofol-sodium metabisulfite causes bronchospasms

Question 11

dose

Answer 11

induction: 1-2.5 mg/kg IV
sedation: 25-100 mcg/kg/min
maintenance: 100-300 mcg/kg/min
antiemetic 10-20 mg IV