Physostygmine Flashcards
1
Q
class
A
anticholinestersae
2
Q
structure
A
tertiary amine
crosses BBB and GI tract
3
Q
mech of action
A
forms a carbamyl ester complex at the esteratic site of the enzyme, decreasing ACh metabolism and increasing levels at the NMJ
4
Q
Vd
A
1 L/kg
5
Q
elimination
A
hydrolyzed at its ester linkage by cholinesterases and renal excretion is minimal
6
Q
onset
doa
T1/2
A
onset: 5 min
doa: 0.5-5 hr
T1/2: 15-40 min
7
Q
side effects
A
decreases SVR, BP, HR
bronchoconstriction
increases saliva, gastric secretion
8
Q
contraindications
A
GI/GU obstruction
caution with cardiovascular disease
depolarizing NMB
9
Q
other
A
can be used for OD of: atropine scopalomine IA benzos opioids barbs
10
Q
dose
A
15-60 mcg/kg for treatment of contral anti-cholinergic syndrome
may need repeat q 1-2 hr
