PUO in a rural context Flashcards
Which disease can you consider is a patient with water exposure?
Leptospirosis
What is the definition of PUO?
Fever >38.3 on several occasions
Over 3 weeks
Uncertain diagnosis after 3 weeks of Ix
What do you think of in a fever in a farmer?
Q fever
Farmers lung
Psittacosis
How long do you treat IE with abx?
4 weeks IV
What are the common infectious causes of PUO?
TB
Infective endocarditis - particularly subacute
Intraabdominal abscess (amoebic)
HIV
What are some causes of PUO that are on the rise?
Vasculitis
Drugs
Which travel infection can be excluded if it present >3 month after return?
P falciparum
Dengue
How do you characterise caues of PUO?
Infectious
Inflammatory
Malignancy
Other
What type of cells do you get in Hodgkin’s lymphoma?
Reid-Sternberg cells
TB presenting one year after aquisition is typically what form of the disease? Why?
Miliary TB
The immune system hasn’t controlled it
What are the common inflammatory causes of PUO?
Vasculitis
Autoimmune
Granulomatous
How long do you treat septic arthritis with abx?
10-14 days IV
4 weeks oral
How does lymphoma cause pancytopenia?
Cytokine effect
(Not necessarily bone marrow infiltration)
What does hepatosplenomegaly make you think in the setting of PUO?
Malignancy
- Lymphoma
- Other haematological malignancy
Likely chronic cause of inflammation
What must be you beware of with CRP?
CRP rise often occurs after the symptoms
