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Respiratory Week 3 > Pulmonary Vascular Disease Pathology > Flashcards

Pulmonary Vascular Disease Pathology Flashcards

1
Q

what will chest X ray look like with PE?

A

normal

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2
Q

what is a drug that is a risk factor for DVT and PE?

A

oral contraceptives

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3
Q

name the coagulation genetic disorder that is a risk factor for PE?

A

factor V leiden

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4
Q

what is the name of the infarct that PE lead to?

A

wedge infarcts

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5
Q

what goes on in the wedge infarct? 2 things

A

hemorrhage and necrosis

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6
Q

name the four steps in development of PH in vessels

A

medial hypertrophy
intimal proliferation
intimal fibrosis
plexiform vascular lesion

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7
Q

describe what a plexiform vascular lesion looks like

A

totally blocked off vessel that looks like it is trying to recanalize with diffuse pink spots

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8
Q

what antibodies are associated with microscopic polyangitis?

A

MPO antibodies

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9
Q

what antigen is associated with granulomatis with polyangitis?

A

PR3 antigen

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10
Q

what appearance will diffuse alveolar hemoptysis disorders have on X ray?

A

diffuse ground glass opacities

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11
Q

name the three alveolar hemorrhage syndromes to know

A

goodpasture syndrome
acute lupus pneumonitis
granulomatous poly angitis

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12
Q

how is goodpasture syndrome mediated?

A

antibodies bind to antigen directly on the surface of the basement membrane of small vessels

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13
Q

what are goodpasture auto antibodies against?

A

type IV collagen in basement membrane

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14
Q

what two organs mainly suffer from goodpastures?

A

kidney and lung

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15
Q

how can you see goodpasture auto antibodies?

A

in serum or in immunofloresence (IF)

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16
Q

will goodpasture have a linear or splotchy appearance in basement membrane?

A

linear

17
Q

how is acute lupus pneumonitis mediated?

A

auto antibodies bind in blood and form complex that deposits in basement membrane of small capillaries

18
Q

is acute lupus pneumonitis patchy or smooth in appearance in basement membrane?

A

patchy because deposits will happen wherever they can

19
Q

how is granulomatour polyangitis mediated?

A

antibodies bind the neutrophils and activate them…leading to necrotizing granulomatour vasculitis

20
Q

describe granulomatous polyangitis in three words

A

necrotizing granulomatous vasculitis

21
Q

what is the antibody in granulomatour polyangitis?

A

ANCA

22
Q

what does granulomatour polyangitis lead to?

A

nodules that can cavitate

Respiratory Week 3 (14 decks)

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