Pulmonary Vascular Disease Pathology

Question 1

what will chest X ray look like with PE?

Answer 1

normal

Question 2

what is a drug that is a risk factor for DVT and PE?

Answer 2

oral contraceptives

Question 3

name the coagulation genetic disorder that is a risk factor for PE?

Answer 3

factor V leiden

Question 4

what is the name of the infarct that PE lead to?

Answer 4

wedge infarcts

Question 5

what goes on in the wedge infarct? 2 things

Answer 5

hemorrhage and necrosis

Question 6

name the four steps in development of PH in vessels

Answer 6

medial hypertrophy
intimal proliferation
intimal fibrosis
plexiform vascular lesion

Question 7

describe what a plexiform vascular lesion looks like

Answer 7

totally blocked off vessel that looks like it is trying to recanalize with diffuse pink spots

Question 8

what antibodies are associated with microscopic polyangitis?

Answer 8

MPO antibodies

Question 9

what antigen is associated with granulomatis with polyangitis?

Answer 9

PR3 antigen

Question 10

what appearance will diffuse alveolar hemoptysis disorders have on X ray?

Answer 10

diffuse ground glass opacities

Question 11

name the three alveolar hemorrhage syndromes to know

Answer 11

goodpasture syndrome
acute lupus pneumonitis
granulomatous poly angitis

Question 12

how is goodpasture syndrome mediated?

Answer 12

antibodies bind to antigen directly on the surface of the basement membrane of small vessels

Question 13

what are goodpasture auto antibodies against?

Answer 13

type IV collagen in basement membrane

Question 14

what two organs mainly suffer from goodpastures?

Answer 14

kidney and lung

Question 15

how can you see goodpasture auto antibodies?

Answer 15

in serum or in immunofloresence (IF)

Question 16

will goodpasture have a linear or splotchy appearance in basement membrane?

Answer 16

linear

Question 17

how is acute lupus pneumonitis mediated?

Answer 17

auto antibodies bind in blood and form complex that deposits in basement membrane of small capillaries

Question 18

is acute lupus pneumonitis patchy or smooth in appearance in basement membrane?

Answer 18

patchy because deposits will happen wherever they can

Question 19

how is granulomatour polyangitis mediated?

Answer 19

antibodies bind the neutrophils and activate them…leading to necrotizing granulomatour vasculitis

Question 20

describe granulomatous polyangitis in three words

Answer 20

necrotizing granulomatous vasculitis

Question 21

what is the antibody in granulomatour polyangitis?

Answer 21

ANCA

Question 22

what does granulomatour polyangitis lead to?

Answer 22

nodules that can cavitate