ILD Pathology

Question 1

in sarcoidosis, in the lungs what are the two common findings?

Answer 1

granulomas

hilar lymphadenopathy

Question 2

what is another name for hypersensitivity pneumonitis?

Answer 2

extrinsic allergic alveolitis

Question 3

what is seen histologically in hypersensitiity pneumonitis?

Answer 3

bilateral interstitial linear or nodular pattern inflammation granulommas

Question 4

how do granulommas in hypersens pneumonitis appear?

Answer 4

they are patchy and loosely formed

Question 5

what cells predominate the granulomas in hypersens pneumonitis?

Answer 5

lymphocytes and histios with giant cells

Question 6

what does pneumoconiosis mean?

Answer 6

dust in the lung

Question 7

what are the two fibrogenic causes of pneumoconiosis?

Answer 7

silica

asbestosis

Question 8

what is the inert cause of pneumoconiosis?

Answer 8

coal

Question 9

is silicosis in upper or lower lobes? what does it look like on X ray?

Answer 9

upper looks nodular

Question 10

what causes the formations of nodules in silicosis?

Answer 10

deposition of fibroblasts that lay down collagen

Question 11

what is the shape of asbestos?

Answer 11

fibers… long and sharp

Question 12

where does the response to asbestos occur? what is it called?

Answer 12

in the sub pleural space…patchy sub pleural fibrosis

Question 13

what is a ferruginous body? what does it look like? what disease?

Answer 13

it is a asbestos deposit…looks like a barbell..in asbestosis in lungs

Question 14

where does coal pneumoconiosis occur?

Answer 14

in the interstitium

Question 15

what drug does IPF not respond to?

Answer 15

steroids

Question 16

what does it mean for IPF to be spatially and temporally hetergenous?

Answer 16

spatially means fibrosis can be next to normal lung

temporally means fibrosis can be at different stages in different locations of the lungs

Question 17

where does UIP mainly occur in the lung? how is it described?

Answer 17

sub pleural

patchy sub pleural infiltrates

Question 18

what is buzz word for describing UIP end stage disease?

Answer 18

honeycomb disease

Question 19

what are the two types of temporal fibrosis you can see in UIP?

Answer 19

fibroblastic and fibrotic

Question 20

what is the difference in fibroblastic and fibrotic tissue?

Answer 20

fibroblastic means it is active and has more cells (fibroblasts) laying stuff down
fibrotic is pinker and acellular that does not have fibroblasts

Question 21

the granulomas in sarcoidosis have what type of structure?

Answer 21

very tight and non necrotizing

Question 22

what is a common animal that has organic antigens that can cause hypersensitivity pneumonitis?

Answer 22

BIRD

Question 23

describe the pathology of hypersesnitivity pneumonitis

Answer 23

patchy peri bronchiolar and interstitial chronic inflammation….loosely formed granulomas