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Respiratory Week 3 > Anti-Tussives and Decongestants > Flashcards

Anti-Tussives and Decongestants Flashcards

1
Q

what is the drug name of mucinex?

A

Guaifenesin

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2
Q

what is the mechanism of Guaifenesin?

A

not sure…but makes mucus thinner

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3
Q

what is the mechanism of N acetylcysteine?

A

it breaks disulfide bonds in the mucin and makes it thinner

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4
Q

what is the name of the reducing agent that is a cough drug?

A

N-acetylcysteine

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5
Q

what is the name of the peripherally acting anaesthetic that helps with cough?

A

benzonatate

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6
Q

what is the mechanism of benzonatate?

A

it blocks Na channels in neurons so signal cannot be transmitted from the irritant receptors

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7
Q

what is the drug name of robitussin?

A

dextromethorphan

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8
Q

what is the mechanism of action of dextromethorphan?

A

it inhibits glutamate in the CNS and prevent signalling to the brain

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9
Q

what is the mechanism of action of codeine?

A

inhibits Ca influx in presynaptic terminals and allow K+ influx to hyperpolarize the post synatpic cell

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10
Q

name the two centrally acting anti-tussives

A

codeine and dextromethorphan

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11
Q

what is the drug name of sudafed and sudafed PE?

A

Pseudophedrine and Phenylephrine respectively

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12
Q

what is the mechanism of action of pseudophedrine and phenylephrine to treat congestion?

A

cause vasoconstriction of mucus membranes since they are a1 agonists

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13
Q

what is the drug name of benadryl?

A

Diphenhydramine

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14
Q

name the two 1st generation anti histamines?

A

diphenhydramine and Promethazine

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15
Q

name the three 2nd generation anti histamines?

A

Loratidine
fexofenidine
Ceterizine

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16
Q

what is the difference between 1st and 2nd generation anti histamines?

A

1st can cross the blood brain barrier and second cannot

17
Q

what effect does 1st generation anti histamines have in brain?

A

can lead to sedation..drowsiness on benadryl is common

18
Q

what histamine receptors do 1st and 2nd generation anti histamines attack?

A

H1 receptor

19
Q

how many histamine receptors are there?

A

4..H1-4

20
Q

what histamine receptors are found in nasal mucosal endothelium?

A

just H1

Respiratory Week 3 (14 decks)

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