Anti-Tussives and Decongestants Flashcards
what is the drug name of mucinex?
Guaifenesin
what is the mechanism of Guaifenesin?
not sure…but makes mucus thinner
what is the mechanism of N acetylcysteine?
it breaks disulfide bonds in the mucin and makes it thinner
what is the name of the reducing agent that is a cough drug?
N-acetylcysteine
what is the name of the peripherally acting anaesthetic that helps with cough?
benzonatate
what is the mechanism of benzonatate?
it blocks Na channels in neurons so signal cannot be transmitted from the irritant receptors
what is the drug name of robitussin?
dextromethorphan
what is the mechanism of action of dextromethorphan?
it inhibits glutamate in the CNS and prevent signalling to the brain
what is the mechanism of action of codeine?
inhibits Ca influx in presynaptic terminals and allow K+ influx to hyperpolarize the post synatpic cell
name the two centrally acting anti-tussives
codeine and dextromethorphan
what is the drug name of sudafed and sudafed PE?
Pseudophedrine and Phenylephrine respectively
what is the mechanism of action of pseudophedrine and phenylephrine to treat congestion?
cause vasoconstriction of mucus membranes since they are a1 agonists
what is the drug name of benadryl?
Diphenhydramine
name the two 1st generation anti histamines?
diphenhydramine and Promethazine
name the three 2nd generation anti histamines?
Loratidine
fexofenidine
Ceterizine
what is the difference between 1st and 2nd generation anti histamines?
1st can cross the blood brain barrier and second cannot
what effect does 1st generation anti histamines have in brain?
can lead to sedation..drowsiness on benadryl is common
what histamine receptors do 1st and 2nd generation anti histamines attack?
H1 receptor
how many histamine receptors are there?
4..H1-4
what histamine receptors are found in nasal mucosal endothelium?
just H1
