ARDS Pathology Flashcards
how does ARDS appear on Xray?
patchy areas of ground glass opacity
describe the pathology of ARDS? what cells are injured and what cell proliferates?
endothelial or epithelial injury leads to type II pneumocytes proliferating
what two things occur in the acute phase of ARDS?
exudate into alveoli
hyaline membrane formation surrounding the alveoli
what lung cell proliferates in ARDS?
type II pneumocyte
what molecule is lacking in ARDS?
surfactant
what molecule makes up the hyaline membrane? how does it look histologically?
fibrin
smooth pink lines surrounding alveoli
what is the main histologic characteristic of the proliferative phase of ARDS?
fibrosis in the interstitium
the atelectasis and resulting hypoxia can lead to what in respiratory distress of newborns?
epithelial necrosis
what can form that can be seen histologically in respiratory distress of infants?
hyaline membrane in intra-alveolar space
what does COP stand for?
cryptogenic organizing pneumonia
how can you treat COP?
with prednisone
how does COP look on an X-ray/CT?
patchy airspace infiltrates
what can COP lead to in the bronchioles?
fibromyxoid plugs
what is the characteristic finding in airspaces for COP?
fibroblastic proliferation filling the airways
in what lung lobe does aspiration usually settle?
right lower lobe
