Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

P&T > Pulmonary pharmacology > Flashcards

Pulmonary pharmacology Flashcards

0
Q

Antibody that is cross-linked by allergens and activates mast cell degranulation, producing asthma symptoms

A

IgE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

3 effects of alpha adrenergic stimulation

A
  1. smooth muscle contraction
  2. vasoconstriction
  3. slight bronchoconstriction
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Th cells that are important in cell-mediated immunity and intracellular pathogens

A

Th1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

3 effects of beta-1 adrenergic stimulation

A
  1. tachycardia
  2. arrhythmia
  3. HTN
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Major effect beta-2 stimulation

A

bronchodilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Th cells that can cause chronic inflammation and are thought to be associated with neutrophilic asthma

A

Th17

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

A severe whole body response to an allergen leading to smooth muscle constriction, vasodilation (hypotension) and increased vascular permeability

A

anaphylaxis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Enzyme that is inhibited by PKA (via phosphorylation) that catalyzes muscle contraction

A

Myosin light chain kinase (MLCK)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

G-alpha subunit that is associated with beta-2 receptors

A

Gs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

The standard emergency treatment for anaphylaxis

A

epinephrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

3 ultra-long acting beta-2 agonist

A
  1. indacaterol
  2. olodaterol
  3. vilanterol
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Th cells that are important in antibody-related immunity and extracellular pathogens and are thought to be associated with eosinophilic asthma

A

Th2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Traditional Chinese remedy for asthma that is a non-selective adrenergic agonist

A

Ephedrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Drug class of theophylline

A

methylxanthine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Zone for the cortex that is responsible for producing mineralcorticoids (aldosterone)

A

zona glomerulosa (outer)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

2 long-acting inhaled beta-2 agonists

A
  1. salmeterol (Serovent)

2. formoterol (Foradil)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

The gold standard short-acting beta-2 agonist

A

albuterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

3 MOAs of theophylline

A
  1. phosphodiesterase inhibitor
  2. adenosine receptor antagonist
  3. activation of histone deacetylases
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

2 IV beta-2 agonists

A
  1. terbutaline

2. epinephrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Zone of the cortex that is responsible for producing sex hormones

A

zona reticularis (inner)

20
Q

Long-acting beta-2 agonist that is a partial agonist

A

salmeterol xiafoate

21
Q

Region of the adrenal gland that secretes mineralcorticoids, glucocorticoids and sex hormones

A

Cortex (outer region)

22
Q

2 major problems with theophylline, largely limiting its use

A
  1. low therapeutic index

2. many drug interactions

23
Q

MOA of roflumilasat

A

Phosphodiesterase 4 inhibitor

24
Q

Muscarinic receptor that is mostly active in airway smooth muscle contraction and mucus hyper-secretion

A

M3

25
Q

The first line of defense for treating COPD

A

anticholinergics

26
Q

2 oral beta-2 agonists

A
  1. terbutaline

2. albuterol

27
Q

Region of the adrenal gland that secretes catacholamines

A

Medulla (inner region)

28
Q

Structural difference between anticholinergics used to treat COPD and atropine

A

agents used to treat COPD are quaternary amines

29
Q

Zone of the cortex that is responsible for producing glucocorticoids

A

zona fasciculata (middle)

30
Q

The precursor for cortisol

A

cholesterol

31
Q

Where ACTH is released from

A

pituitary gland

32
Q

Protein that translocates free cholesterol to the mitochondria and transports cholesterol from the outer membrane to the inner membrane

A

Steriodogenic acute regulator protein

33
Q

Hormone that regulates the zona fasciculata and the production of glucocorticoids

A

Adrenocorticotropic hormone (ACTH)

34
Q

MOA of zilueton

A

5’- lipoxygenase inhibitor

35
Q

Muscarinic receptors that are presynaptic and ideally would not be inhibited

A

M2

36
Q

Location of the adrenal gland

A

above the kidneys

37
Q

3 MOAs of theophylline that relate to asthma

A
  1. Phosphodiesterase inhibitor
  2. adenosine receptor antagonist
  3. activation of histone deacetylases
38
Q

MOA of decongestants (phenylephrine and pseudophedrine)

A

alpha-1 adrenergic receptor agonists

41
Q

G alpha subunit associated with alpha-1 adrenergic receptor

A

Gq

42
Q

1st line maintenance therapy for asthma

A

ICS

43
Q

2 Mast cell stabilizers

A
  1. Cromolyn

2. Nedocromil

45
Q

Maximum usage time of topical nasal decongestants

A

every 12 hours for no longer than 3-5 days

46
Q

Standard dosing regimen of cromolyn (mast cell stabilizer) for maintenance treatment of asthma

A

2 inhalations qid

47
Q

Target of montelukast

A

LT1 receptor

48
Q

GPCR alpha subtype in LT1 receptor

A

Gq

49
Q

Condition characterized by vicious cycle of nasal decongestant therapy followed by congestion

A

rhinitis medicamentosa

50
Q

G-alpha subunit associated with H1 receptor

A

Gq

51
Q

2 major effects of histamine H1 receptor activity

A
  1. NO-mediated relaxation of smooth muscle, vasodilation

2. MLCK-mediated contraction capillary endothelium, making capillaries leaky

P&T (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions