Parkinson's therapeutics

Question 0

4 classic features of PD

Answer 0

tremor
rigidity
akinesia/bradykinesia
postural instability

Question 1

Neuronal, cytoplasmic, filamentous aggregates composed of the presynaptic protein, alpha-synuclein

Answer 1

Lewy bodies

Question 2

2 anticholinergics that can be helpful in initial treatment of tremor and rigidiy

Answer 2

trihexyphenidyl

benztropine

Question 3

Dopamine agonist that requires dose adjustment for renal function

Answer 3

pramiprexole

Question 4

D1, D2 and D2 receptor agonist that is a transdermal patch

Answer 4

rotigotine

Question 5

Antipsychotic medications that have been specifically studied in PD patients

Answer 5

clozapine and quetiapine

Question 6

Antipsychotic that has shown and increased chance on worsening motor symptoms

Answer 6

olanzapine

Question 7

5 antidepressants that have shown positive results in PD patients

Answer 7

Nortriptyline, desipramine, venlafaxine, citalopram, paroxetine