Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

P&T > Pain therapeutics > Flashcards

Pain therapeutics Flashcards

0
Q

Only FDA indication for lidocaine 5% patch

A

post herpetic neuralgia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

The normal processing of stimuli

A

nociceptive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

An inbalance of pro-nociceptive and anit-nociceptive stimuli

A

dysfunctional pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

The drug of choice for trigeminal neuralgia

A

crbamazepine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

MOA of gabapentin and pregabalin

A

bind to alpha-2-delta subunit of N-type Ca channels and block them

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

FDA approved used of gabapentin regarding pain

A

post herpetic neuralgia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Abnormal processing of sensory input that is caused by direct damage to the nervous system or persistent stimulaton of the nervous system by another pain source

A

neuropathic pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Minimum effective dose of gabapentin

A

600 mg TID

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

FDA approval of pregabalin regarding pain

A

post herpetic neuralgia, diabetic peripheral neuropathy and fibromyalgia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Minimum effective dose of pregabalin

A

150 mg/day in 2-3 divided doses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

MOA of katamine

A

NMDA receptor antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

MOA of TCAs

A

5HT/NE reuptake inhibition and Na channel block

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

5 cautions with TCAs

A
  1. BPH
  2. arrhythmia (QT prolongation)
  3. suicidal idealization
  4. hepatic failure
  5. renal failure
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Opioid that is the most useful in neuropathic pain

A

Methadone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

4 groups of 1st line agents for neuropathic pain

A
  1. TCAs
  2. Gabapentin and pregabalin
  3. Lidocaine patch (post herpetic neurophathy)
  4. SNRI (diabetic peripheral neuropathy)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

3 groups of second line agents for neuropathic pain

A
  1. tramadol
  2. opioids
  3. capsaicin
18
Q

2 opioids that are the most common for a patient to have a true allergy to

A

codeine and morphine

19
Q

enzyme that metabolizes codeine to morphine

A

CYP2D6

21
Q

4 opioids that have a risk of serotonin toxicity

A
  1. fentanyl
  2. tramadol
  3. meperidine
  4. methadone
23
Q

the 4 A’s of pain

A
  1. Analgesia
  2. Adverse effects
  3. Activities of daily living
  4. Aberrant opioid-related behaviors
25
Q

Opioid that has the worst nausea side effects

A

Codeine

26
Q

enzyme that metabolizes hydrocodone to hydromophone

A

CYP2D6

27
Q

Toxic metabolite of meperidine that has a longer half-life and no analgesic action

A

normeperidine

28
Q

4 C’s of addiction

A
  1. Loss of control
  2. Continued use despite adverse consequences
  3. Compulsion to use
  4. Cravings
30
Q

MOA of meperidone

A

Strong mu agonist and NMDA agonist

31
Q

The gold standard for the treatment of moderate-severe pain

A

Morphine

32
Q

Neurotoxic metabolite of hydromorphone

A

H3G

33
Q

Enzyme that catalyzes conversion of oxycodone to noroxycodone, a non-active, non-toxic metabolite

A

CYP3A4

34
Q

Enzyme that catalyzes conversion of oxycodone to oxymorphone, an active metabolite

A

CYD2D6

35
Q

Sole route of metabolism of fentanyl

A

CYP3A4

36
Q

MEQ that is defined as non-opioid naive

A

> 60 mg MEQ for the past 7 days

37
Q

Black box warning for methadone

A

cardiac toxicity and QT prolongation at >60 mg/day

38
Q

Abnormal behavior developing as a direct consequence of inadaquate pain management

A

Pseudoaddiction

39
Q

Any drug deviation from the medical plan

A

aberrant behaviors

40
Q

Patient population to avoid morphine in in order to decrease risk of opioid neurotoxicity

A

morphine

41
Q

2 opioids that have the lowest risk of neurotoxicity

A

methadone and fentanyl

42
Q

Damage to solid or hollow organs that is poorly localized and often associated with nausea and diaphoresis

A

Visceral pain

43
Q

NSAID that has the lowest CV risk

A

Naproxen

50
Q

Damage to bone, muscle, ligament or skin that is usually well localized

A

Somatic pain

P&T (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions