Pain Pharmacology

Question 0

Pain that permits the localization of pain and discriminates among different types of pain

Answer 0

somatic

Question 1

Amount of time that qualifies pain as chronic

Answer 1

3 months

Question 2

Pain that activates circuits in the brain that produces negative emotions

Answer 2

Affective pain

Question 3

Brain region that is important in fear

Answer 3

amygdala

Question 4

Nociceptive fibers that are unmyelinated and have a conduction speed of less than 2 sec

Answer 4

C fibers

Question 5

MOA of pentazocaine

Answer 5

partial mu agonist and k agonist

Question 6

receptors that mediate long lasting increase in excitability of dorsal horn neurons

Answer 6

NMDA receptors

Question 7

4 AAs that are at the N-terminus of all endogenous opioid receptor agonists

Answer 7

Tyr-Gly-Gly-Phe

Question 8

4 endogenous opioid receptor agonists

Answer 8

B-endorphin
Met-enkephalin and Leu-enkephalin
Dynorphin

Question 9

MOA of buprenorphine

Answer 9

partial mu agonist and possible k antagonist

Question 10

4 effects of mu-opioid receptors

Answer 10

1. analgesia
2. sedation
3. inhibition of respiration
4. slowed GI transit

Question 11

3 effects of kappa-opioid receptors

Answer 11

1. analgesia
2. psychometic effects
3. slowed GI transit

Question 12

inactive metabolite of morphine with neurotoxic properties

Answer 12

M3G

Question 13

MOA of butorphanol

Answer 13

partial mu agonist and k agonist

Question 14

active metabolite of morphine that is more active than the parent

Answer 14

M6G

Question 15

Mechanism by which respiratory depression du to opioids is mediated

Answer 15

me receptor-mediated

Question 16

Main MOA of lidocaine

Answer 16

blocks Na channel function

Question 17

MOA of methadone

Answer 17

mu receptor agonist and NMDA receptor antagonist

Question 18

Opioid antagonist that is used in alcohol addiction

Answer 18

Naltrexone

Question 19

MOA of tramadol metabolite

Answer 19

weak mu receptor agonist

Question 20

Stimuli that normally do not cause pain now cause pain

Answer 20

Allodynia

Question 21

MOA of nalbuphine

Answer 21

mu antagonist and k agonist

Question 22

FDA approved use of methylnaltrexone

Answer 22

refractory opioid-induced constipation in patients with acute illness receiving palliative care

Question 23

mechanism by which euphoria due to opioids is mediated

Answer 23

mu receptor-mediated

Question 24

Mechanism by which nausea/vomiting due to opioids is mediated

Answer 24

activation of chemoreceptor trigger zone

Question 25

released from free nerve endings and activates adjacent nociceptive neurons by binding to NKI receptors and contributes to pain and inflammation

Answer 25

Substance P

Question 26

3 actions of Gi/o opioid receptor channels

Answer 26

1. open K channels 2. closing Ca channels 3. inhibit adenylate cyclase

Question 27

MOA of aspirin

Answer 27

irreversibly inhibits COX via acetylation

Question 28

ligand-gated non-selective ion channel on C fiber sensory neurons that capsaicin activates

Answer 28

transient receptor potential vanilloid (TRPVI) receptor

Question 29

MOA of triptans

Answer 29

1B/1D receptor agonist

Question 30

An intrathecal spinal infusion of come snail venom

Answer 30

Zoconitide

Question 31

3 effects of substance P

Answer 31

1. vasodilation 2. aids in generation of bradykinin from kininogen 3. release of histamine from mast cells

Question 32

2 side effects of opioids that patients do not develop tolerance to

Answer 32

1. constipation | 2. Miosis

Question 33

An alkaloid derived from plants of the Solanacae family that causes local depletion of Substance P

Answer 33

Capsaicin

Question 34

MOA of zoconitide

Answer 34

blocks presynaptic N-type Ca channels, decreasing excitatory neurotransmitter release

Question 35

Opioid antagonist that is the primary agent used for opioid overdose

Answer 35

Naloxone

Question 36

MOA of methylnaltrexone

Answer 36

peripherally acting mu-opioid receptor antagonist

Question 37

MOA of tramadol parent drug

Answer 37

5HT/NE reuptake inhibition

Question 38

nociceptive neurons that are thinly myelinated and have a conduction speed of 20 m/sec

Answer 38

Adelta fibers