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P&T > Pain Pharmacology > Flashcards

Pain Pharmacology Flashcards

0
Q

Pain that permits the localization of pain and discriminates among different types of pain

A

somatic

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1
Q

Amount of time that qualifies pain as chronic

A

3 months

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2
Q

Pain that activates circuits in the brain that produces negative emotions

A

Affective pain

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3
Q

Brain region that is important in fear

A

amygdala

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4
Q

Nociceptive fibers that are unmyelinated and have a conduction speed of less than 2 sec

A

C fibers

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5
Q

MOA of pentazocaine

A

partial mu agonist and k agonist

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6
Q

receptors that mediate long lasting increase in excitability of dorsal horn neurons

A

NMDA receptors

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7
Q

4 AAs that are at the N-terminus of all endogenous opioid receptor agonists

A

Tyr-Gly-Gly-Phe

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8
Q

4 endogenous opioid receptor agonists

A

B-endorphin
Met-enkephalin and Leu-enkephalin
Dynorphin

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9
Q

MOA of buprenorphine

A

partial mu agonist and possible k antagonist

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10
Q

4 effects of mu-opioid receptors

A
  1. analgesia
  2. sedation
  3. inhibition of respiration
  4. slowed GI transit
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11
Q

3 effects of kappa-opioid receptors

A
  1. analgesia
  2. psychometic effects
  3. slowed GI transit
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12
Q

inactive metabolite of morphine with neurotoxic properties

A

M3G

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13
Q

MOA of butorphanol

A

partial mu agonist and k agonist

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14
Q

active metabolite of morphine that is more active than the parent

A

M6G

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15
Q

Mechanism by which respiratory depression du to opioids is mediated

A

me receptor-mediated

16
Q

Main MOA of lidocaine

A

blocks Na channel function

17
Q

MOA of methadone

A

mu receptor agonist and NMDA receptor antagonist

18
Q

Opioid antagonist that is used in alcohol addiction

A

Naltrexone

19
Q

MOA of tramadol metabolite

A

weak mu receptor agonist

20
Q

Stimuli that normally do not cause pain now cause pain

A

Allodynia

21
Q

MOA of nalbuphine

A

mu antagonist and k agonist

22
Q

FDA approved use of methylnaltrexone

A

refractory opioid-induced constipation in patients with acute illness receiving palliative care

23
Q

mechanism by which euphoria due to opioids is mediated

A

mu receptor-mediated

24
Q

Mechanism by which nausea/vomiting due to opioids is mediated

A

activation of chemoreceptor trigger zone

25
Q

released from free nerve endings and activates adjacent nociceptive neurons by binding to NKI receptors and contributes to pain and inflammation

A

Substance P

26
Q

3 actions of Gi/o opioid receptor channels

A
  1. open K channels
  2. closing Ca channels
  3. inhibit adenylate cyclase
27
Q

MOA of aspirin

A

irreversibly inhibits COX via acetylation

28
Q

ligand-gated non-selective ion channel on C fiber sensory neurons that capsaicin activates

A

transient receptor potential vanilloid (TRPVI) receptor

29
Q

MOA of triptans

A

1B/1D receptor agonist

30
Q

An intrathecal spinal infusion of come snail venom

A

Zoconitide

31
Q

3 effects of substance P

A
  1. vasodilation
  2. aids in generation of bradykinin from kininogen
  3. release of histamine from mast cells
32
Q

2 side effects of opioids that patients do not develop tolerance to

A
  1. constipation

2. Miosis

33
Q

An alkaloid derived from plants of the Solanacae family that causes local depletion of Substance P

A

Capsaicin

34
Q

MOA of zoconitide

A

blocks presynaptic N-type Ca channels, decreasing excitatory neurotransmitter release

35
Q

Opioid antagonist that is the primary agent used for opioid overdose

A

Naloxone

36
Q

MOA of methylnaltrexone

A

peripherally acting mu-opioid receptor antagonist

37
Q

MOA of tramadol parent drug

A

5HT/NE reuptake inhibition

38
Q

nociceptive neurons that are thinly myelinated and have a conduction speed of 20 m/sec

A

Adelta fibers

P&T (18 decks)

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