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Pharmacology > Psychomotor stimulants > Flashcards

Psychomotor stimulants Flashcards

1
Q

This drug contains an asymmetric carbon. The d isomer exerts the greater effect in the CNS.

A

amphetamine

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2
Q

This is a prodrug of amphetamine linked to lysine. It is used for ADHD.

A

Lisdexamfetamine

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3
Q

This has methyl groups and incresed lipid solubility making it resistant to metabolism. It produces intense CNS effects. It is also called crank, speed, ice.

A

methamphetamine

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4
Q

This drug is used for ADHD and paradoxical effect stimulates locus ceruleus enabling focus.

A

Methylphenidate

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5
Q

This drug is marketed as bath salts. It is found in khat plant leaves.

A

cathinone

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6
Q

This is a natural product found in some herbal preparations.

A

Ephedrine

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7
Q

These drugs are used for treatment of narcolepsy or shift work disorders.

A

Modafanil, armodafanil

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8
Q

What are the CNS effects of amphetamine (other)?

A

Arousal, wakefulness, euphoria, dysphoria, decline performance, rebound crashing effect, tolerance, dependence, withdrawal, paranoid schizophrenia, suppress appetite

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9
Q

What is the mode of action of amphetamine (others)?

A

Increase release NE,DA
Inhibit reuptake of NE,DA
Stimulate alpha receptors in reward center
decrease DA in reward center (chronic)

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10
Q

Inhalation of what form of cocaine provides a very rapid delivery to the brain?

A

Lipid soluble free base form

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11
Q

This drug is a powerful reinforcer.

A

cocaine

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12
Q

Which drugs may inhibit behavioral effects of cocaine?

A

antipsychotic by blocking dopamine receptors

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13
Q

This drug is used in the treatment of asthma.

A

Theophylline

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14
Q

This drug is used in the treatment of severe asthma.

A

Aminophylline

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15
Q

What drugs may be used to treat apnea in preterm infants?

A

caffeine, theophylline

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16
Q

What are the purposed MoA of caffeine?

A

Inhibit phosphodiesterase
blockade of adenosine receptors
release of calcium

17
Q

This drug acts as an antagonist at glycine receptors in the spinal cord. Leads to development of severe toxic seizures.

A

Strychnine, rat poison.

Use diazepam to control seizures

18
Q

This produces tetanus and tonic convulsions.

A

Tetanus toxin by clostridum

Pharmacology (13 decks)

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