Psychomotor stimulants Flashcards
This drug contains an asymmetric carbon. The d isomer exerts the greater effect in the CNS.
amphetamine
This is a prodrug of amphetamine linked to lysine. It is used for ADHD.
Lisdexamfetamine
This has methyl groups and incresed lipid solubility making it resistant to metabolism. It produces intense CNS effects. It is also called crank, speed, ice.
methamphetamine
This drug is used for ADHD and paradoxical effect stimulates locus ceruleus enabling focus.
Methylphenidate
This drug is marketed as bath salts. It is found in khat plant leaves.
cathinone
This is a natural product found in some herbal preparations.
Ephedrine
These drugs are used for treatment of narcolepsy or shift work disorders.
Modafanil, armodafanil
What are the CNS effects of amphetamine (other)?
Arousal, wakefulness, euphoria, dysphoria, decline performance, rebound crashing effect, tolerance, dependence, withdrawal, paranoid schizophrenia, suppress appetite
What is the mode of action of amphetamine (others)?
Increase release NE,DA
Inhibit reuptake of NE,DA
Stimulate alpha receptors in reward center
decrease DA in reward center (chronic)
Inhalation of what form of cocaine provides a very rapid delivery to the brain?
Lipid soluble free base form
This drug is a powerful reinforcer.
cocaine
Which drugs may inhibit behavioral effects of cocaine?
antipsychotic by blocking dopamine receptors
This drug is used in the treatment of asthma.
Theophylline
This drug is used in the treatment of severe asthma.
Aminophylline
What drugs may be used to treat apnea in preterm infants?
caffeine, theophylline
What are the purposed MoA of caffeine?
Inhibit phosphodiesterase
blockade of adenosine receptors
release of calcium
This drug acts as an antagonist at glycine receptors in the spinal cord. Leads to development of severe toxic seizures.
Strychnine, rat poison.
Use diazepam to control seizures
This produces tetanus and tonic convulsions.
Tetanus toxin by clostridum
