Antipsychotics

Question 1

This term is referred to drugs used to treat schizophrenia.

Answer 1

Antipsychotic

Question 2

This term refers to the behavioral effects of the drugs in experiments.

Answer 2

Neuroleptic

Question 3

Antipsychotics alleviate psychotic symptoms without?

Answer 3

depressing most other intellectual functions

Question 4

Chlorpromazine and other first generation drugs have a great effect against?

Answer 4

Positive symptoms (delusion, hallucinations, thought disorders)

Question 5

How long does it take for the apparent benefits to be seen?

Answer 5

2-4 weeks, tolerance does not usually develop

Question 6

Which drug can desensitize the chemorecepetor trigger zone, and be used as an antiemetic?

Answer 6

prochlorperazine

Question 7

This results in bizarre muscle spams, facial grimacing, twitching during early onset of therapy. Treatment is?

Answer 7

acute dystonia

trihexiphenydyl

Question 8

Compelling need to be in motion, fidgeting, pacing during early onset of therapy. Treatment is?

Answer 8

Akathisia

propranolol, BZD

Question 9

Tremor and muscular rigidity. Treatment is?

Answer 9

Parkinsonism

Trihexiphenydyl

Question 10

Stupor, severe rigidity, hyperthermia. Treatment is?

Answer 10

Neuroleptic malignant syndrome.
Massive release of Ca from sarcoplasmic reticulum.
Dantrolen or bromocryptine

Question 11

Involuntary movements such as sucking lips, jaw movements, protrusion of tongue. Treatment is?

Answer 11

Tardive dyskinesia.

Suppression more antipsychotics.

Question 12

What drugs can make tardive dyskinesia worse?

Answer 12

anticholinergics

Question 13

Traditional antipsychotics are thought to act at what receptors?

Answer 13

D2 antagonists in the limbic, mesocortical, extrapyramidal areas

Question 14

Which drug is thought to act as D4 antagonist and has high affinity of 5-HT2 receptors?

Answer 14

Clozapine

Question 15

Chlorpromazine blocks the effects of dopamine in what systems?

Answer 15

nigrostriatal, mesolimbic, mesocortical, tuberoinfundibular

Question 16

Clozapine blocks the effects of dopamine and serotonin in what systems?

Answer 16

mesolimbic, mesocortical.

Question 17

Drugs that block what receptors help with negative symptoms of schizophrenia?

Answer 17

Block serotonin receptors

Question 18

Too little dopamine in relation to cholinergic activity results in?

Answer 18

parkinsonism (nigrostriatal)

Question 19

Too much dopamine in relation to cholinergic activity results in?

Answer 19

Tardive dyskinesia

Question 20

This drug is more potent than chlorpromazine, less sedation, less anticholinergic, more EPS.

Answer 20

trifluoperazine

Question 21

This drug is a long acting form given by im as a depot injection every 3-4 weeks.

Answer 21

fluphenazine

Question 22

This drug is similar to trifluoperazine but is used as a antiemetic.

Answer 22

prochlorperazine

Question 23

This drug is less anticholingeric than chlorpromazine, more EPS, less sedation.

Answer 23

Haloperidol

Question 24

This drug has the potential to cause granulocytopenia, agranulocytosis, seizures.

Answer 24

clozapine

Question 25

This drug is effective against some negative symptoms, also used in treatment of suicidal behavior.

Answer 25

clozapine

Question 26

This drug may cause weight gain, hyperglycemia, diabetes type-2, myocarditis, seizures.

Answer 26

Clozapine

Question 27

This is an analog of clozapine, and does not cause bone marrow toxicity.

Answer 27

olanzapine

Question 28

This drug is used for schizophrenia and mania. It is more likely to cause EPS than clozapine.

Answer 28

Olanzapine

Question 29

This drug has more potential for EPS than clozapine or olanzapine. It also can cause weight gain and hyperglycemia.

Answer 29

Risperidone

Question 30

These drugs cause very few EPS, effective against both positive and negative symptoms.

Answer 30

Quetiapine, ziprasidone

Question 31

This drug acts as a partial agonist/antagonist at D2 and 5-HT1a receptors.

Answer 31

aripiprazole

Question 32

What are the high potency drugs? what effects do they cause?

Answer 32

trifluoperazine, fluphenazine, haloperidol Less cardio, anticholinegeric More EPS

Question 33

What are the low potency drugs? what effects do they cause?

Answer 33

chlorpromazine, olanzapine,risperidone More cardio, anticholinergic Less EPS