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Pharmacology > Depression > Flashcards

Depression Flashcards

1
Q

What drugs can induce depression?

A

beta blockers, reserpine

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2
Q

What drugs are used in manic depressive disorders?

A

lithium, antipsychotics, antidepressants

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3
Q

Which drugs are tricyclics?

A

imipramine, amitriptyline

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4
Q

What drugs are the SSRI?

A

Selective serotonin reuptake inhibitors.

fluoxetine, sertraline, paroxetine, fluvoxamine, citalopram, escitalopram

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5
Q

What drugs are SNRI?

A

Selective norepinephrine reuptake inhibitors

venlafaxine, duloxetine, atomoxetine

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6
Q

What are the pharmacologic effects of imipramine?

A

Sedation, antidepressant effect seen in 2-4 weeks, CNS stimulation, decrease seizure threshold

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7
Q

What drugs have a stimulant activity instead of sedation?

A

bupropion, venlafaxine

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8
Q

What drug selectively inhibits DA reuptake?

A

bupropion

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9
Q

What drug inhibits both NE and 5-HT reuptake?

A

venlafaxine

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10
Q

What drugs inhibit the reuptake of 5-HT and block 5-HT2 receptors?

A

trazodone, nefazadone

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11
Q

What are the anticholingeric side effects?

A

dry mouth, constipation, urine retention, loss of visual accommodation

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12
Q

Which drug produces the most anticholingeric side effects?

A

amitriptyline

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13
Q

What are the cardiovascular side effects?

A

postural hypotension, tachycardia, arrhythmias

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14
Q

Treatment of antidepressant overdose is?

A

sodium bicarbonate

Others: CCB, BBlockers, antiarrhythmics

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15
Q

What drugs can cause serotonin syndrome?

A

MAOI and tricyclic combo

wait 2-4 weeks before switching

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16
Q

This drug is a tricyclic antidepressant that is more sedative and anticholinergic than imipramine.

A

amitriptyline

17
Q

These drugs have less sedation, anticholingeric, cardiovascular, weight gain than tricyclics

A

SSRI

18
Q

This drug has less potential for drug interactions than fluoxetine.

A

sertraline

19
Q

This drug is more rapidly metabolized and does not form active metabolite. it also is more likely to cause weight gain.

A

Paroxetine

20
Q

This drug is more likely to produce seizures. Also used in treatment of dependence of opiates or nicotine.

A

bupropion

21
Q

These drugs may be used for ADHD as well as depression.

A

venlafaxine, atomoxatine

22
Q

This is approved for neuropathic pain as well as depression.

A

duloxetine

23
Q

This drug can cause priapism and is very sedating.

A

trazodone

24
Q

This drug block presynpatic alpha-2 receptors. enhance Ne,Se release.

A

mirtazapine

25
Q

This drug is useful for patients with anxiety and depression.

A

mirtazapine

26
Q

This preferentially metabolizes NE and 5-HT.

A

MAO-A

27
Q

This preferentially metabolizes DA.

A

MAO-B

28
Q

This drug is a selective inhibitor of MAO-B

A

Selegeline

29
Q

What is the chronic effect of using MAOI?

A

decreased number and sensitivity of adrenergic and serotonergic receptors

30
Q

This drug can irreversibly inactivate MAO due to forming covalent bonds.

A

Phenelzine

31
Q

This drug binds very tightly to MAO.

A

tranylcypromine

32
Q

What is the greatest problem with using non-selective MAOI?

A

They interact with substances such as tyramine.

33
Q

What MAOI can be used for the treatment of parkinson’s disease?

A

Selegiline

34
Q

Which drug is the most effective for treatment of manic-depressive disorders?

A

Lithium

35
Q

What is the purposed mechanism of lithium?

A

Lithium inhibits the regeneration of inositol in the phosphoinositide signaling pathway

36
Q

What antiepileptic drugs are effective in treatment of manic-depressive disorders?

A

carbamazepine, valproic acid, clonazepam

Pharmacology (13 decks)

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