Depression Flashcards
What drugs can induce depression?
beta blockers, reserpine
What drugs are used in manic depressive disorders?
lithium, antipsychotics, antidepressants
Which drugs are tricyclics?
imipramine, amitriptyline
What drugs are the SSRI?
Selective serotonin reuptake inhibitors.
fluoxetine, sertraline, paroxetine, fluvoxamine, citalopram, escitalopram
What drugs are SNRI?
Selective norepinephrine reuptake inhibitors
venlafaxine, duloxetine, atomoxetine
What are the pharmacologic effects of imipramine?
Sedation, antidepressant effect seen in 2-4 weeks, CNS stimulation, decrease seizure threshold
What drugs have a stimulant activity instead of sedation?
bupropion, venlafaxine
What drug selectively inhibits DA reuptake?
bupropion
What drug inhibits both NE and 5-HT reuptake?
venlafaxine
What drugs inhibit the reuptake of 5-HT and block 5-HT2 receptors?
trazodone, nefazadone
What are the anticholingeric side effects?
dry mouth, constipation, urine retention, loss of visual accommodation
Which drug produces the most anticholingeric side effects?
amitriptyline
What are the cardiovascular side effects?
postural hypotension, tachycardia, arrhythmias
Treatment of antidepressant overdose is?
sodium bicarbonate
Others: CCB, BBlockers, antiarrhythmics
What drugs can cause serotonin syndrome?
MAOI and tricyclic combo
wait 2-4 weeks before switching
This drug is a tricyclic antidepressant that is more sedative and anticholinergic than imipramine.
amitriptyline
These drugs have less sedation, anticholingeric, cardiovascular, weight gain than tricyclics
SSRI
This drug has less potential for drug interactions than fluoxetine.
sertraline
This drug is more rapidly metabolized and does not form active metabolite. it also is more likely to cause weight gain.
Paroxetine
This drug is more likely to produce seizures. Also used in treatment of dependence of opiates or nicotine.
bupropion
These drugs may be used for ADHD as well as depression.
venlafaxine, atomoxatine
This is approved for neuropathic pain as well as depression.
duloxetine
This drug can cause priapism and is very sedating.
trazodone
This drug block presynpatic alpha-2 receptors. enhance Ne,Se release.
mirtazapine
This drug is useful for patients with anxiety and depression.
mirtazapine
This preferentially metabolizes NE and 5-HT.
MAO-A
This preferentially metabolizes DA.
MAO-B
This drug is a selective inhibitor of MAO-B
Selegeline
What is the chronic effect of using MAOI?
decreased number and sensitivity of adrenergic and serotonergic receptors
This drug can irreversibly inactivate MAO due to forming covalent bonds.
Phenelzine
This drug binds very tightly to MAO.
tranylcypromine
What is the greatest problem with using non-selective MAOI?
They interact with substances such as tyramine.
What MAOI can be used for the treatment of parkinson’s disease?
Selegiline
Which drug is the most effective for treatment of manic-depressive disorders?
Lithium
What is the purposed mechanism of lithium?
Lithium inhibits the regeneration of inositol in the phosphoinositide signaling pathway
What antiepileptic drugs are effective in treatment of manic-depressive disorders?
carbamazepine, valproic acid, clonazepam
