Psychiatry Clerkship_2 Flashcards
what % of patients treated with lithium show partial reduction of mania?
70%
long term use of lithium reduces what?
suicide risk
what is the mortality rate in acute overdose of lithium?
25%
what is the action of carbamazepine and valproate in BpID?
anticonvulsant and mood stabilizer
what are the indications and risks for use of anticonvulsants in BpID?
they are especially useful for rapid cycling BpD and mixed episodes, although associated with ↑ risk for suicide
what are the atypical antipsychotics used in BpID?
olanzapine • quetiapine • ziprasidone
how are atypical antipsychotics useful for treatment of BpID?
they are effective as both monotherapy and adjunct therapy for acute mania, with careful monitoring of adverse effects
what is the role of antidepressants in the treatment of BpID?
they are discouraged as monotherapy due to concerns of activating mania or hypomania. the addition of antidepressants as adjunctive therapy to mood stabilizers has not shown to be effective
what is the role of psychotherapy in the treatment of BpID?
supportive psychotherapy, family therapy, group therapy (prolongs remission once the acute manic episode has been controlled)
what is the role of ECT in BpID?
-works well in treatment of manic episodes • - especially effective for refractory or life threatening acute mania or depression
what is the difference between ECT for bipolar vs depression?
bipolar usually requires more treatment than depression
bipolar II disorder is alternately called what?
recurrent major depressive episodes with hypomania
DSM IV criteria for diagnosis of BpIID?
hx of >=1 MDE and >=1 hypomanic episode, without EVER having a manic episode in the past
which is more prevalent bp1d or bp2d?
bp2d
what is the gender predilection of bp2d?
slightly more common in women
when is the onset of bp2d?
onset usually before age 30
what is the ethnic predilection of bp2d?
no ethnic differences
how is bp2d misdiagnosed?
frequently misdiagnosed as unipolar depression and thereby mistreated
what are the course and prognosis of bp2d?
tends to be chronic, requiring long term tx
what is the treatment for bp2d?
same as bp1d
what are the sytmptoms of dysthymic disorder?
CHASES • Concentration/decision difficulty • Hopelessness • Appetite ↑↓ • Sleep disturbance • Energy ↓ • Self esteem ↓
what is the difference between MDD and dysthymic disorder?
MDD tends to be episodic, while dysthymic disorder is generally persistent
what do patients with dysthymic disorder look like?
they have chronic, mild depression most of the time with no dicrete episodes. they rarely need hospitalization
what are the DSM IV criteria for diagnosis of dysthymic disorder?
- depressed mood for the majority of time most days for at least 2 years (or 1 in kids) • 2. >2: • - poor concentration • - feelings of hopelessness • - poor appetite • - insomnia/hypersomnia • - low energy • - low self esteem • 3. during 2 years: • - the person has not been without the above symptoms for > 2 months at a time • - no MDE • - no hx mania or hypomania
what is double depression?
patients with major depressive disorder with dysthymic disorder during residual periods
what is the lifetime prevalence of dysthymic disorder?
6%
what is the gender predilection in dysthymic disorder?
2-3x more common in women
when is the typical onset of dysthymic disorder?
before 25yo in 50%
what is the course and prognosis of dysthymic disorder?
20% of patients will develop major depression, 20% will develop bpd, >25% will have lifelong symptoms
what is the treatment for dysthymic disorder?
- cognitive therapy and insight oriented psychotherapy are most effective • 2. antidepressant medications are useful when used concurrently with psychotherapy
what is cyclothymic disorder?
alternating periods of hypomania and periods with mild to moderate depressive symptoms
what are the DSM IV criteria for diagnosis of cyclothymic disorder?
- numerous periods with hypomanic symptoms and periods with depressive symptoms for at least 2 years • 2. person must never have been symptom free for > 2 mo during those 2 years • 3. no hx of MDE or manic episode
what is the lifetime prevalence of cyclothymic disorder?
<1%
cyclothymic disorder may coexist with which Axis II?
borderline personality disorder
when is the onset of cyclothymic disorder?
usually age 15-25
what is the gender predilection in cyclothymic disorder?
M=F
what is the course and prognosis of cyclothymic disorder?
chronic course • 1/3 of patients are eventually diagnosed with bpd
what is the tx for cyclothymic disorder?
antimanic agents as used to treat bpd
what is minor depressive disorder?
episodes of 2-4 depressive symptoms that do not meet the full five or more for MDD, euthymic periods are also seen • - still associated with functional impairments • - 18% may fit the criteria for MDD in 1 year
what is the triad for seasonal affective disorder?
- irritability • 2. carb craving • 3. hypersomnia
criteria for diagnosis of seasonal affective disorder?
> 2 consecutive years of 2 MDE during the same season • - often respond to light therapy
criteria for diagnosis of postpartum major depression?
onset within 4 weeks of delivery
adjustment disorders happen when?
when maladaptive behavioral or emotional symptoms develop after a stressful life event
when does adjustment disorder happen?
symptoms begin within 3 months after the event, end within 6 months, and cause significant impairment in daily functioning or interpersonal relationships
DSM-IV criteria for adjustment disorder?
- development of emotional or behavioral symptoms within 3 months after a stressful life event. these symptoms produce either: • - severe distress in excess of what would be expected after such an event • - significant impairment in daily functioning • 2. the symptoms are not those of bereavement • 3. symptoms resolve within 6 months after stressor has terminated
what are the subtypes of adjustment disorders?
based on predominance of: • - depressed mood • - anxiety • - disturbance of conduct (aggression) • - combinations of the above
how common are adjustment disorders?
very common
what is the gender predilection in adjustment disorders?
2x more common in females
what is the typical age of onset of adjustment disorder?
most frequently diagnosed in adolescents but may occur at any age
what is the difference between PTSD and adjustment disorder?
adjustment disorder= not life threatening stressor event • PTSD= life threatening traumatic event
what is the etiology of adjustment disorders?
triggered by psychosocial factors
what is the prognosis of adjustment disorders?
may be chronic if the stressor is recurrent; symptoms resolve within 6 months of cessation of stressor
what is the tx of adjustment disorder?
- supportive psychotherapy (most effective) • 2. group therapy • 3. pharmacotherapy for associated symptoms (insomnia, anxiety, depression)
what are the symptoms of anxiety?
- cardiac: • - palpitations, tachycardia, hypertension • 2. pulmonary: • - SOB, choking sensation • 3. neurologic • - dizziness, light-headedness, hyperreflexia, mydriasis (dilation), tremors, tingling in the peripheral extremities • 4. psychological: • - restlessness (pacing), “butterflies in the stomach” • 5. other: • - sweating, gastrointestinal, urinary urgency and frequency
what is anxiety?
the subjective experience of fear and its physical manifestations
what is the difference between physiologic and pathologic anxiety?
pathologic anxiety= symptoms interfere with daily functioning and response is inappropriate
which neurotransmitters have been implicated in anxiety?
↑NE • ↓GABA, 5-HT
what are the medical causes of anxiety?
- hyperthyroidism • 2. B12 deficiency • 3. hypoxia • 4. neurological disorders (epilepsy, brain tumor, MS, cerebrovascular disease) • 5. cardiovascular disease • 6. anemia • 7. pheochromocytoma • 8. hypoglycemia
what are the medication or substance induced anxiety disorders?
- caffeine intake and withdrawal • 2. theophylline • 3. amphetamines • 4. etOH and sedative withdrawal • 5. other illicit drug withdrawal • 6. mercury or arsenic toxicity • 7. organophosphate or benzene toxicity • 8. penicillin • 9. sulfonamides • 10. sympathomimetics • 11. antidepressants
what is the lifetime prevalence of anxiety in women?
30%
what is the lifetime prevalence of anxiety in men?
19%
in which socioeconomic group is anxiety disorder more common?
higher income
types of anxiety disorders include what?
- panic disorder • 2. agoraphobia • 3. specific and social phobias • 4. OCD • 5. PTSD • 6. acute stress disorder • 7. generalized anxiety disorder • 8. anxiety disorder secondary to general medical condition • 9. substance induced anxiety disorder
what are the panic attack criteria?
PANICS • 1. palpitations • 2. abnormal stress • 3. numbness, nausea • 4. intense fear of death • 5. choking, chills, chest pain • 6. sweating, shaking, SOB
panic attacks are associated with conditions such as what?
- mitral valve prolapse • 2. asthma • 3. pulmonary embolus • 4. angina • 5. anaphylaxis
what are panic attacks?
discrete periods of heightened anxiety and fear that classically occur in patients with panic disorder, but can also be seen with other anxiety disorders (phobic disorders, PTSD)
what is the onset and timing of panic attacks?
peak within 10 minutes and last <25 minutes
what causes panic attacks?
they may be provoked by triggers or come spontaneously
to diagnose a panic attacks the patient must have what?
> 4: • 1. palpitations • 2. sweating • 3. shaking • 4. SOB • 5. choking sensation • 6. chest pain • 7. nausea • 8. light headedness • 9. depersonalization • 10. derealization • 11. fear of losing control • 12. fear of dying • 13. numbness or tingling • 14. chills or hot flashes
panic disorder is characterized by what?
spontaneous recurrent panic attacks with no obvious precipitant
how often do patients with panic disorder get panic attacks?
average: • - 2x/wk • range: • - several/day - few/year
what happens between panic attacks in a patient with panic disorder?
anticipatory anxiety is common
what are the DSM IV criteria for diagnosis of panic attack?
> 1 attack must be followed by >1 of the following: • 1. persistent concern about having additional attacks • 2. worry about the implications of the attacks • 3. a significant change in behavior related to the attacks • – rule out other causes in dDx of panic attack • – always specify whether panic disorder is w/ or w/o agoraphobia
more than 40% of patients presenting with chest pain and normal angiograms may have what?
panic disorder
what are the conditions in the medical dDx for panic disorder?
chf • angina • MI • thyrotoxicosis • temporal lobe epilepsy • MS • pheochromocytoma • carcinoid syndrome • COPD
what are the medications/drugs in the dDx for panic disorder?
intoxication: • amphetamine • caffeine • nicotine • cocaine • hallucinogens • • etOH or opiate withdrawal
what are the other psychiatric disorders commonly associated with panic disorder?
depressive disorders • phobic disorders • OCD • PTSD
panic disorder is associated with dysregulation of which physiological systems?
SNS • CNS • cerebral blood flow
panic disorder is related to changes in which neurotransmitter activity?
↑NE • ↓ 5HT and GABA
panic attacks may be induced by what?
caffeine, nicotine, hyperventilation
what is the lifetime prevalence panic disorder?
2-5%
what is the gender predilection in panic disorder?
3x more common in females than males
what how strong is the genetic predisposition for panic disorder
4-8x greater risk of panic disorder if 1st degree relative is affected
when is the typical onset for panic disorder?
late teens to early thirties, but may occur at any age
how should SSRI therapy be managed in panic disorder patients?
always start SSRI at a low dose and ↑ slowly b/c some SSRI’s can have side effects that may initially worsen anxiety
what are the course and prognosis of panic disorder?
variable course but is often chronic • relapses are common with d/c of medical therapy • -10-20 % of patients continue to have significant symptoms that interfere with daily functioning • - 50% continue to have mild infrequent symptoms • - 30-40% remain free of symptoms after treatment
what are the characteristic situations avoided in agoraphobia?
bridges • crowds • buses • trains • any open areas outside the home
what are the common specific phobias?
animals • heights • blood or needles • illness or injury • death • flying
what is the best long term treatment for panic disorder?
SSRI’s, especially paroxetine and sertraline, and at higher doses than for depression
what are the other antidepressants that can be used for panic disorder?
clomipramine • imipramine
what is the role of benzodiazepines in panic disorder treatment?
they are effective immediately but are best used temporarily b/c of their risk for abuse and dependency
how long should treatment for panic disorder continue?
> =8-12 months, as relapse is common after discontinuation of therapy
what are the nonpharmacological treatments for panic disorders?
relaxation training, biofeedback, cognitive therapy, insight-oriented psychotherapy
what are the common social phobias?
speaking in public • eating in public • using public restrooms
what is agoraphobia?
the fear of being alone in public places
what does the anxiety in agoraphobia lead to?
the avoidance of being in places or situations from which escape or help might be difficult
agoraphobia often develops secondary to what?
panic attacks- due to apprehension about having subsequent attacks in public places where escape may be difficult
what % of agoraphobia coexists with panic disorder?
50-75%
what happens to agoraphobia when coexisting panic disorder is treated?
it usually resolves
what happens when agoraphobia is not associated panic disorder?
it is usually chronic and debilitating
what is required for a person with shyness to be diagnosed with social phobia?
the provoked anxiety has to interfere with their daily functioning
what conditions are commonly comorbid with phobias?
substance disorders, esp etoh • 1/3 of phobic patients also have associated major depression
performance anxiety is often successfully treated with what?
beta blockers
what is a specific phobia ?
a strong, exaggerated fear of a specific object or situation
what is a social phobia?
social anxiety disorder- • a fear of social situations in which embarrassment can occur
what are the DSM IV criteria for the diagnosis of specific phobias?
- persistent excessive fear brought on by a specific situation or object • 2. exposure to the situation brings about an immediate anxiety response • 3. patient recognizes that fear is excessive • 4. the situation is avoided when possible or tolerated with intense anxiety • 5. if person is under age 18, duration must be at least 6 months
what are the DSM IV diagnostic criteria for social phobia?
same as for specific phobia except that the feared situation is related to social settings in which the patient might be embarrassed or humiliated in front of other people
what are the most common mental disorders in the united states?
phobias
what percent of the population is affected with a phobic disorder?
5-10%
which is more common, specific or social phobia?
specific
what is the range of onset for phobias?
5 yo for seeing blood • 35 yo for situational (like heights)
when is the average age of onset for social phobias?
mid teens
what is the gender predilection of specific phobias?
2x F:M
what is the gender predilection in social phobia?
M=F
what is the cause of phobias?
most likely multifactorial, with genetic and neurochemical factors playing a role
what is systemic desensitization?
the gradual exposure of a patient to a feared object or situation while teaching relaxation and breathing techniques
what is flooding?
directly confronting the patient with their full fear
what is the difference between shyness and social phobia?
in social phobia is there is complete avoidance of scrutiny and exaggerated fears in day to day life that cause significant distress and/or disability
what is the treatment for specific phobia?
- pharmacologic treatment has not been found effective • 2. behavior therapy is most effective and systemic desensitization (graded exposure/flooding) is a common technique • 3. if necessary, a short course of benzos or beta blockers may be used during desensitization to help control autonomic symptoms
what is the treatment for social phobia?
- paroxetine is FDA approved for the treatment of social anxiety disorder • 2. beta blockers are frequently used for performance anxiety • 3. cognitive and behavioral therapies are useful adjuncts
what is an obsession?
a recurrent and intrusive thought, feeling, or idea that is ego dystonic
what is a compulsion?
a conscious repetitive behavior linked to an obsession that, when performed, functions to relieve anxiety caused by the obsession
what is OCD?
an axis I disorder in which patients have obsessions that ↑ their anxiety level. they usually relieve this with compulsions
do patients with OCD typically have insight?
yes they are generally aware of their problems and realize that their thoughts and behaviors are irrational
what are the DSM IV criteria for diagnosis of OCD?
Either or of: • 1. Obsessions: • - repetitive and intrusive • - cause anxiety, but not simple worries about real worries • - attempts to suppress thoughts • - realizes thoughts are product of own mind • 2. Compulsions: • - repetitive behaviors in response to obsessions • - behaviors aimed at reducing distress, but not realistically linked to it • - aware that obsessions and compulsions are unreasonable and excessive • - obsessions cause distress and interfere with life
compulsions can often take the form of what?
repeated checking • very specific rituals
patients with OCD often present in what setting?
in other specialty like dermatology to treat “skin condition” related to frequent hand washing
what % of OCD patients have both obsessions and compulsions?
75%
which disorders are frequently comorbid with OCD?
Tourette’s and OCD
what is the lifetime prevalence of OCD?
2-3%
when is typical onset of OCD?
early adulthood
what is the gender predilection in OCD?
m=f
OCD is associated with which conditions?
MDD • eating disorders • other anxiety disorders • OCPD
the rate of OCD is higher in patients with first degree relatives who have what?
Tourette syndrome
what is the neurochemical etiology of OCD?
associated with abnormal regulation of serotonin
what is the genetic etiology of OCD?
higher in first degree relatives and monozygotic twins than general population
what medical conditions can cause OCD?
head injury • epilepsy • basal ganglia disorders • postpartum conditions
what are the psychosocial etiologies of OCD?
the onset of OCD is triggered by a stressful life event in approximately 60% of patients
what is the course and prognosis for OCD?
usually chronic with ~30% significantly improving with treatment, 40-50% moderate improvement, 20-40% remain significantly impaired
what are the pharmacologic treatments for OCD?
SSRI’s are the first line at higher than normal doses • TCA’s