Psychiatry/behavioral Flashcards
Delusional disorder
1 or more delusions lasting more than a month without other psychotic symptoms
Brief psychotic disorder
1 or more psychotic symptoms with onset and remission <1month
Schizophreniform disorder
Meets criteria for schizophrenia but duration <6month
Schizoaffective disorder
Schizophrenia with a mood disturbance
Schizophrenia
2 or more of the following:
Positive sx-hallucinations, delusions, disorganized speech/thinking, abnormal behavior
Negative sx-flat affect, social withdrawal, avolition
For 6 months or more with at least 1 month acute symptoms
Who gets schizophrenia?
MC in males with family hx, presents in early 20s
Presents in late 20s in women
1st line treatment for schizophrenia
2nd gen antipsychotics: risperidone, olanzapine, quetiapine
Typical 1st gen antipsychotics
BUTYROPHENONES: haloperidol and droperidol
PHENOTHIAZINES: fluphenazine, perphenazine, chlorpromazine, thioridazine
Side effects of antipsychotics
Extrapyramidal sx, neuroleptic malignant syndrome, QT prolongation, arrhythmias, sedation, anticholinergic sx, dermatitis, increased prolactin, weight gain
EPS and increased prolactin worse in 1st gen/typical antipsychotics
Chlorpromazine and thioridazine have less __________ symptoms but more ___________ symptoms
Extrapyramidal
Anticholinergic
Describe extrapyramidal symptoms
- dystonic reaction (intermittent spasms with sustained involuntary muscle contraction) occurs hours to days after initiating antipsychotics
- Tardive dyskinesia (akathisia) seen with long term use of antipsychotics
- Parkinsonism (rigidity, tremor, Bradykinesia)
Akathisia
Restlessness
Tx for dystonic reaction
IV diphenhydramine
Describe neuroleptic malignant syndrome (NMS)
D2 inhibition leads to mental status change, muscle rigidity, tremor, autonomic instability-tachycardia, tachypnea, hyperthermia
Tx for NMS
Stop offending agent
lower temp with cooling blankets
dopamine agonist: bromocriptine, amantadine, levodopa/carbidopa, dantrolene
When does NMS usually occur?
In young adults within 90d of antipsychotic initiation/dose increase
C/I-cautions for Haldol
Parkinson’s disease, anticoagulant use, severe cardiac disease
Describe anticholinergic symptoms
Dry mouth, blurred vision(dilated pupils), urinary retention, constipation, dry skin, flushing, tachycardia, fever, htn, and delirium
Atypical 2nd generation antipsychotics
Quetapine (Seroquel)
Olanzapine (zyprexa)
Clozapine
Loxapine
Unique side effects of clozapine
Agranulocytosis (CBC monitored weekly)
Myocarditis, QT prolongation
Seizures
Unique side effects of olanzapine
Weight gain and diabetes mellitus
Benzioxazoles
Risperidone (Risperdal)
Ziprasidond (Geodon)
Indications for benzisoxazoles
Schizophrenia, bipolar, psychosis
*Risperdal also used in Tourette’s
Indication for Abilify
Psychotic disorders
*sometimes called a 3rd generation antipsychotic
Indication for lithium
Bipolar disorder -acute mania
SE of lithium
Hypothyroidism Diabetes insipidus Hyperparathyroidism Seizures HA Tremor Sedation Arrhythmia N&V Diarrhea Weight gain
*narrow therapeutic index. Monitor q 4-8wk
Anticonvulsants used to suppress impulsive or aggressive behavior
Valproate and carbamazepine
How long must you have depressed mood/anhedonia/loss of interest in activities to be dx with MDD?
2wks
*symptoms must cause distress or impairment and mania or hyponania must be absent
Key symptom in atypical depression
Mood reactivity
Tx of atypical depression
MAO inhibitors
How prevalent is suicide in depression?
15% of pts commit suicide
Especially men 25-30 and women 40-50
Higher rates in pts with detailed plan, White males >45, and concurrent substance abuse
PHQ 2
- Little interest/enjoyment of things
2. Feeling down, depressed, or hopeless
PHQ 9
- Little interest
- Feeling down/hopeless
- Difficulty sleeping/hypersomnia
- Fatigue/low energy
- Appetite or weight changes
- Self disappointment
- Trouble concentrating
- Psychomotor changes (slow movement or speech, irritability, restlessness)
- Passive or active suicidal thoughts
Tx of MDD
1st line: SSRI or SNRI
2nd line: Bupropion or mirtazapine
3rd line: TCAs or MAO inhibitors
Continue for a minimum 3-6wk to determine efficacy
Selective serotonin reuptake inhibitors(SSRIs)
Citalopram (Celexa) Ecitalopram (Lexapro) Paroxetine (Paxil) Fluoxetine (Prozac) Sertraline (Zoloft) Fluvoxamine (Zyvox)
*1st line for depression and anxiety
SE of SSRIs
GI upset, sexual dysfunction, HA, changes in energy, anxiety, insomnia, weight changes, SIADH
Avoid using citalopram in pts with ___________.
Long QT syndrome
SSRI + MAO inhibitor =
Serotonin syndrome
SNRI + St. John’s Wart=
Serotonin syndrome
MAOI + TCA=
Delirium and hypertension
Sx of serotonin syndrome
Acute AMS seizures Restlessness Diaphoresis Tremor Hyperthermia N&V Abd pain Mydriasis Tachycardia
Serotonin Norepinephrine Reuptake inhibitors (SNRIs)
Venlafaxine (Effexor)
Desvenlafaxine (Pristiq)
Duloxetine (cymbalta)
SNRIs are particularly good first line agents for MDD in patients with ______________ or ______________
Significant fatigue
Pain syndromes
SE of SNRIs
Same as SSRIs plus htn and dizziness
Mirtazapine (Remeron)
Antidepressant with less sexual dysfunction
SE of Mirtazapine
Sedation Dry mouth Constipation Weight gain Agranulocytosis
Bupropion indication
Wellbutrin for depression *less GI distress and sexual dysfunction than SSRIs
Zyban for smoking cessation
SE of bupropion
Seizures Agitation Anxiety Restlessness Weight loss HTN HA
Bupropion C/I
Seizure disorders
Eating disorders
MAOI use
ETOH/drug detox
Tricyclics antidepressants (TCAs)
Amitriptyline Clomipramine Desipramine Doxepin Imipramine Nortriptyline
SE of TCAs
Anticholinergic, sedation, weight gain, prolonged QT
TCA overdose
Wide complex tachycardia
Neurological symptoms
ARDS
SIADH
MAO inhibitors
Non selective: phenelzine, tranylcypromine, isocarboxazid
Selective: selegiline
SE of MAOI
Insomnia Anxiety Orthostatic hypotension Weight gain Sexual dysfunction Hypertensive crisis
Pts on MAOIs must avoid these foods or it may lead to hypertensive crisis
Tyramine-containing foods
Bipolar I disorder
1 or more manic or mixed episode which often cycles with occasional depressive episodes
Strongest risk factor for bipolar I
Family history/1st degree relative
*the earlier the onset the poorer the prognosis and more likely to develops psychotic features
Mania
Abnormal & persistently elevated, expansive or irritable mood for at least 1wk with impaired function
Pharmaceutical treatment of bipolar I
1st line Mood stabilizers: LITHIUM, vampiric acid, carbamazepine
2nd line antipsychotics
Benzodiazepines can be added if psychosis or agitation develops
*antidepressants may precipitate mania
Bipolar II disorder
1 or more hypomanic disorder and 1 or more major depressive episode
Without mania or mixed episodes
Hypomania
Sx are similar to mania but no marked impairment in function
Persistent depressive disorder (dysthymia)
Chronic depressed mood in adults >2yr. Usually milder than MDD and pt is able to function
*may progress to MDD or bipolar in time. Tx same as MDD
Cyclothymic disorder
Similar to bipolar II but less severe, at least 2yr duration
Tx for acute panic attack
Benzodiazepines: lorazepam and alprazolam are 1st line
Panic disorder
Recurrent unexpected panic attacks with worry/concerns about future attacks
Symptoms of panic attack
Dizziness Trembling Choking feeling Paresthesias Sweating SOB chest pain Chills/hot flashes Fear of loading control or dying Palpitations/tachycardia Nausea or abd distress Depersonalization/derealization
Agoraphobia
Anxiety about being in places or situations from which you cannot escape
Management of panic disorder
Long term:SSRIs or SNRIs
CBT
Acute attack: benzo
Generalized anxiety disorder
Excessive anxiety about various aspects of life for >6m
Management of GAD
1st line: SSRI or SNRI
2nd: buspirone (Buspar) -May take several weeks for improvement. Does not cause sedation
3rd: Ben is, BB, TCAs
* psychotherapy
Social anxiety disorder
Persistent fear of social or performance situations that can cause panic attacks (>6m)