Psychiatry Flashcards

1
Q

what is the leading cause of maternal deaths occurring within a year after the end of pregnancy

A

Suicide

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2
Q

what are red flag presentations needing an urgent referral to specialist perinatal mental health team

A

recent significant change in mental state or emergence of new symptoms

new thoughts or acts of violent self harm

new and persistent expressions of incompetence as a mother or estrangement from their baby

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3
Q

when would you consider admission to a mother and baby psychiatric unit

A
rapidly changing mental state 
suicidal ideation 
significant estrangement from infant
pervasive guilt or hopelessness
beliefs of inadequacy as a mother 
evidence of psychosis
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4
Q

questions to ask a mother who may have mental health difficulties

A

do you have new feelings and thoughts which you have never had before, which make you disturbed or anxious?

are you experiencing thoughts of suicide or harming yourself?

are you feeling incompetent as though you can’t cope or estranged from your baby? are these feelings persistent?

do you feel you are getting worse?

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5
Q

when are mental health issues screened for

A

booking appointment

EVERY antenatal appointment

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6
Q

how does pregnancy effect pre-existing mental health problems

A

high rate of relapse for bipolar postnatally

eating disorders often improve in pregnancy (if not risks of IUGR, prematurity etc)

depression often gets worse in pregnancy as mothers want to stop meds. Only stop if v mild and refer for psychological treatment.

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7
Q

what are ‘baby blues’

A

50% of women

brief period of emotional instability

tearful, irritable, anxiety and poor sleep confusion

day 3-10 - self limiting

need support and reassurance

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8
Q

what causes puerperal psychosis

A

bipolar, depression, schizophrenia, organic brain dysfunction

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9
Q

what is peurperal psychosis

A

emergency - needs admission to mother and baby unit

usually presents within 2 weeks of delivery

early symptoms are sleep disturbance and confusion, irrational ideas

mania, delusions, hallucinations and confusion

5% suicide risk
4% infanticide

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10
Q

what is post natal depression

A

tearfulness, irritable, anxiety, lack of enjoyment, poor sleep, weight loss - can present as concerns re baby

onset 2-6 weeks postnatally - lasts weeks to months

effects on bonding, child development, marriage, risk of suicide

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11
Q

what issues need to be considered in the treatment of perinatal disorders

A

risks of untreated illness (to mum and baby)

general principles of prescribing in perinatal period

benefits and harms of specific treatments

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12
Q

what risks are there to the baby in untreated depression

A

Low birth weight
-depends on severity

Pre-term delivery
-depends on severity

Adverse childhood outcomes
-emotional and conduct problems

Poor engagement/bonding with child
-reduced infant learning and cognitive development

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13
Q

general principles of psychiatric prescribing in pregnancy

A
  • try to plan pregnancy
  • decisions personal to patient
  • discuss toxicology issues
  • consider stopping meds, changing meds or lowering dose
  • plan (antenatal monitoring and support, contingency plan, place of delivery, postnatal management)
use drugs with low risk 
lowest dose possible 
be aware of altered pharmacokinetics 
increased screening of fetus 
encourage breast feeding
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14
Q

what do you do if a woman falls pregnant on lithium or sodium valproate

A

dont stop it

refer to obstetrics asap

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15
Q

what are first line antidepressants used in pregnancy

A

SSRIs

no major teratogens

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16
Q

which SSRIs to use

A

sertraline has least placental exposure

fluoxetine is thought to be the safest

risks:
hypertension on new born 
lower birth weight 
increased early birth 
PPH 

Paroxetine - less safe than others

17
Q

can you use tricyclics in pregnancy

A

yes
may be some mid and self limiting neonatal withdrawal

venlafaxine - less evidence

mirtazapine - less evidence

18
Q

recommendations for antidepressants in pregnancy

A

stay on same antidepressants during and after pregnancy

unless mother wants to stop

19
Q

what is the effect of antipsychotics in pregnancy

A

1st generation - been around a long time

2nd generation - risk of weight gain so increases GDM

reduce fertility due to raised prolactin levels

all appear to be safe - no major teratogenicity

20
Q

what is the effect of mood stabilisers in pregnancy

A

need the woman to know she can’t take them during pregnancy before conception

valproate and carbamazepine - most teratogenic, increase neural tube defects

lamotrigine is less bad than other anti-convulsants and mood stabilisers

lithium should be avoided

21
Q

what are the risks of lithium in pregnancy

A

known association with Ebstein’s anomaly (20x risk compared to general population, still only 1/1000 risks)

consider slow reduction pre-conception (can be reintroduced un 2nd or 3rd trimester)

be aware of dose changes in 3rd trimester - increases risk of relapse

consider re-introduction immediately postpartum

can be restarted is theres a bad relapse during pregnancy

22
Q

how do you treat anxiety in pregnancy

A

SSRIs

try to avoid benzodiazapines as they’re generally problematic

zopiclone
-some suggestion of risk

23
Q

what is the impact of psychiatric drugs on breast milk

A

all are exerted in breast milk

mental health is highest priority

lowest dose possible
avoid combinations

time doses to feeds (eg. give dose before longest break between feeds)

less exposure during breast feeding than in utero so it its okay in T3 it’ll be okay in breast feeding

24
Q

1st line drugs in pregnancy as antidepressants, antipsychotics and mood stabilisers

A

Antidepressants - sertraline

antipsychotics - olanzapine, quetiapine (acrid clozapine)

mood stabilisers - antipsychotics, avoid lithium NOT valproate

25
Q

what drug can you definitely not take in breast feeding

A

lithium

26
Q

what is at increased risk if theres substance abuse in pregnancy

A
nutritional deficiency 
VTE
STIs 
Endocarditis/sepsis 
Poor venous access 
Opiate tolerance/withdrawal 
Drug overdose/death 
Domestic abuse and suicide 
IUGR, Stillbirth, SIDs, preterm labour
27
Q

risks of alcoholism in pregnancy

A
miscarriage 
fetal alcohol syndrome (facial deformities, lower IQ, neurodevleopmental delay, epilepsy, hearing, heart and kidney defects) 
withdrawal 
wernicke's
korsakoff
28
Q

risks of cocaine, amphetamine and ecstasy in pregnancy

A

death via stroke and arrhythmias
teratogenic
pre-eclampsia
abruption

IUGR
pre-term labour
miscarriage
developmental delay , SIDS, withdrawal

29
Q

risks of opiates and nicotine in pregnancy

A

opiates cause maternal deaths, neonatal withdrawal, IUGR, SIDS, stillbirth

Nicotine causes miscarriages, abruption, IUGR, stillbirths and SIDS

30
Q

how do you treat substance abuse in pregnancy

A

Methadone programme
Child protection and social work referral
Smear history
Breastfeeding (unless alcohol, HIV, cocaine)
Labour plan
Early IV access
Postnatal contraception plan