Psychiatry Flashcards
SSRI
Fluoxetine
Paroxetine
Sertraline
Citalopram/escitalopram
Which SSRI is contraindicated in pregnancy
Paroxetine
Which SSRI is safe for MI
Fluoxetine
SNRI
Venaflaxine
Desvenaflexine
Duloxetine
Indications for SNRI
For treating depression AS WELL AS anxiety (75% depression 25% anxiety)
Venlafaxine contraindication
- Diastolic Hypertension
- Breast feeding
Antipsychotics
Order from lowest to highest potency
Aripiprazole
Quetiapine
Olanzapine
Risperidone
Clozapine
Amisulpride??
Common adverse effect of Antipsychotics
Hyperprolactinemia (>2000 mIU/L)
galactorrhea
gynaecomastia
sexual dysfunction
infertility
amenorrhoea
Examples of Overvalued Ideas
Body dysmorphic disorder
Anorexia Nervosa
Hypochondriasis
Features of Schizophrenia
Positive symptoms
Negative symptoms
Disorganised thought
Hallucinations
Negative symptoms of Schizophrenia
flat affect
poverty of thought
lack of motivation
social withdrawal
reduced speech output
Positive symptoms of Schizophrenia
delusions
hallucinations
thought disorder
disorganized speech and behavior
Drug of choice for Bipolar disorder
Lithium
Haloperidol (Emergency, if uncooperative)
Eating disorders are commonly associated with what patient profiles (history)
– Female Adolescent
– Low self-esteem
– Personal or family history of depression
– Family history of obesity
– High personal expectations
– Family history of eating disorders
– Disturbed family interactions
- Social factors
- Childhood sexual abuse
- Perfectionism and obssessionality
Common clinical features of Anorexia Nervosa
- < 16 BMI
- Significant electrolyte disturbance (K < 3.0 or Na < 130)
– Amenorrhoea
– Constipation.
– Cold intolerance.
– Cachexia.
– Hypothermia.
– Bradycardia. (< 40bpm)
– Hypotension (< 90mmHg) - Raised liver enzymes and Albumin < 35g/L
Complications of Anorexia Nervosa
– low level of LH, FSH and TSH
- secondary amenorrhoea due to low levels of LH and FSH
-Depression
-Obsessive-compulsive disorder
- increased risk of developing bone fractures in later life due to osteoporosis
Causes of Serotonin Syndrome
Serotonin antagonist
SSRI
MAOi
TCA (perhaps)
Symptoms of Serotonin Syndrome
features that differ from NMS
– Muscle weakness, clonus and hyperreflexia
- Rapid Onset (<24hrs)
- Dose dependant
- Nausea and vomiting
- Increased bowel sounds
- Dilated pupils
features shared with NMS
- High grade fever (>40 degrees)
– Autonomic instability (hypertension, tachycardia, diarrhoea, muscle spasms & red skin, sweating).
– Mental state change (agitation, confusion, hypomania, seizure).
- Hypersalivation
-Use of benzodiazepines
Treatment of Serotonin Syndrome
- Cyproheptadine
- Chlorpromazine
St John’s Wort with antidepressant causes
Serotonin syndrome
Causes of Neuroleptic Malignant Syndrome (NMS)
- anti-emetics
- anti-psychotics
- Dopamine antagonists
- cessation of a dopamine agonist
Medications that cause Neuroleptic Malignant Syndrome (NMS)
- quetiapine
- olanzapine
- risperidone
- paliperidone
- domperidone
- metoclopramide
-promethazine
Symptoms of Neuroleptic Malignant Syndrome (NMS)
Features that differ from SS
-Slow onset
- Not dose dependant
- pupils are normal
- No nausea and vomiting
-severe muscle rigidity with hyporeflexia
Features share with SS
- High grade fever (>40 degrees)
– Autonomic instability (hypertension, tachycardia, diarrhoea, muscle spasms & red skin, sweating).
– Mental state change (agitation, confusion, hypomania, seizure).
- Hypersalivation
- Use of benzodiazepines
Treatment of NMS
Bromocriptine
Difference between dementia & pseudodementia?
Cognitive impairment due to the presence of a mood-related mental health concern, most often depression (giving up).
Pseudodementia have INSIGHT
Long-term use of haloperidol
Tardive Dykinesia
Clinical features of Obsessive Compulsive Disorder
- obsessive thoughts and compulsive rituals
- Compulsions are repetitive purposeful, intentional behaviours conducted to prevent an adverse outcome
- Mild obsessional or compulsive behaviour can be considered as a reasonable response to stress
- SSRIs are the treatment of choice
Patients suffering from BPD are at high risk of
Suicide
Capgras syndrome
- Also called delusional misidentification syndrome
- Disorder in which a person believes that an identical-looking has replaced a friend, spouse, parent, or other close family member impostor
- commonly occurs in patients with paranoid schizophrenia,
dementia and brain injury
CAGE questionnaire:
C- Have you ever felt you should Cut down on your drinking?
A- Have people Annoyed you by criticizing your drinking?
G- Have you ever felt bad or Guilty about your drinking?
E- Have you ever had a drink first thing in the morning to steady your nerves or to get rid of a hangover? (Eye-opener)
How much time needs to progress until regular grief becomes pathological?
Complicated: > 6 months in stage 2
Complex: < 6 months with stages alternation
Difference between Complicated Grief Disorder & Avoidant personality disorder?
Complicated grief:
- symptoms persist longer than six months
- Avoidance of situations that serve as reminders of the loss is also common
Avoidant Personality Disorder:
Initial treatment for Hoarding personality disorder?
CBT and SSRI
Which of the following disorders warrant CBT PLUS medication
Obsessive Compulsive Disorder (CBT in the form of exposure & response prevention)
Prolonged excessive cannabis abuse initial treatment
CBT
Most common side-effect of Clozapine?
- Low WBC (agranulocytosis)
- recurrent infections
- metabolic syndrome
- hypersalivation
- sedation
OCD patients are egosyntonic or egodystonic with how they view their disorder?
Egodystonic
1st line treat for malignant catatonia?
ECT
Hypochondriacs come for cause in relation to their…?
Diagnosis
Criteria for Somatic Symptom Disorder
-1 or more somatic symptoms that are distressing or result in significant disruption of daily life
- Excessive thoughts, feelings, or behaviors related to the somatic symptoms or associated health concerns as manifested by at least one of the following:
1. Disproportionate and persistent thoughts about the seriousness of one’s symptoms.
2. Persistently high level of anxiety about health or symptoms.
3. Excessive time and energy devoted to these symptoms or health concerns.
C. Although any one somatic symptom may not be continuously present, the state of being symptomatic is persistent (typically more than 6 months)
Difference between hypochondriasis & Illness anxiety disorder
hypochondriasis: already have a diagnosis failure to respond to reassurance is an explicit criterion
illness anxiety disorder: has as its primary focus preoccupation with having or acquiring a serious (and undiagnosed) medical illness (think general overall health)
Diagnostic criteria for Conversion Disorder
A. One or more symptoms of altered voluntary motor or sensory function.
B. Clinical findings provide evidence of incompatibility between the symptom and recognized neurological or medical conditions.
C. The symptom or deficit is not better explained by another medical or mental disorder.
D. The symptom or deficit causes clinically significant distress or impairment in social, occupational, or other important areas of functioning or warrants medical
evaluation.
Individuals with conversion disorder conversion disorder have symptoms that simulate or mimic
neurological illness. Typical symptoms include paralysis, abnormal movements, inability to speak (aphonia), blindness, and deafness. Pseudoseizures are also
common and may occur in individuals with genuine epileptic seizures. Individuals with conversion disorders are commonly seen on neurology wards and on psychiatry consultation-liaison services at general hospitals
Methamphetamine antidote
Wait it out?
Activated charcoal of option is given history of patient ingesting within 2 hours
Methamphetamine withdrawal treatment of choice?
No proper medication to treat withdrawal. but to treat symptoms that arise such as mood disorders in which case : TCA
Methamphetamine overdose can cause what fatal symptoms?
- Stroke
-seizures
-hyperthermia
how to treat sympathomimetic symptoms?
Agitation: benzodiazepines (lorazepam IV if not cooperative, diazepam oral if patient cooperative)
Hypertension: nitrates (nitroprusside), beta blockers (metoprolol 2-5mg IV)
Hyperthermia: evaporative cooling, icepacks and maintenance of intravascular volume and urine flow with IV normal saline solution.
Seizures: Phenothiazines as last resort
Drug-induced extra-pyramidal disease features
- common in the elderly
- due diminished brain dopamine stores
- caused by neuroleptic drugs
- Tardive dyskinesia is the primary symptom
- Treatment is to cease offending neuroleptic
Tardive dyskinesia vs Parkinsons disease
identical symptoms:
- rigidity
- bradykinesia
- postural instability
Differentiating symptoms:
- involuntary movements of face and tongue (tardive)
- Stiffness
Projection
attribution of one’s feelings or beliefs to another
Idealization
the exaggeration of an individual’s qualities by an admirer
Conversion
transformation of psychologic stressors into physical complaints
Symbolization
the selection of a particular object or event to represent other meanings
Splitting
psychologic separation of all good qualities into one
individual and all bad qualities into another
Sertraline and ecstasy drug interaction
They are synergistic
(increase concentration of serotonin in the
body)
Main characteristic of BPD
Difficulty/Inability to main personal relationships (close friend or romantic partner)
Difference between BPD and Cyclothymic disorder?
BPD:
- impulsivity in at least two areas that are potentially self-damaging
- A pattern of unstable and intense interpersonal relationships characterized by alternating between extremes of idealization and devaluation
Dialectical behaviour therapy
Cyclothymic:
- many periods of depressed mood and many
episodes of hypomanic mood for at least 2 years
- During the above 2-year period (1 year in children and adolescents), the hypomanic and depressive periods have been present for at least half the time and the individual has not been without the symptoms for more than 2 months at a time
Saint John’s Wort combined with COCP
- SJW reduces the effectiveness of COCs and increases the risk of unintended pregnancy
- SJW’s extracts have been reported to induce the cytochrome P450 enzymes CYP1A2, CYP2C9 and CYP3A4, and increase intestinal P-glycoprotein expression. stimulating the liver to break down the oestrogen and progestogen constituents of the COC pill more rapidly, making COCs less effective and increasing chance of unintended pregnancy
St John’s Wort and warfarin
SJW reduces the effectiveness of warfarin and increases the risk of stroke, ischaemia, arterial blockage etc.
- SJW’s extracts have been reported to induce the cytochrome P450 enzymes CYP1A2, CYP2C9 and CYP3A4, therefore metabolising warfarin at a faster rate therefore decreasing its effectiveness.
What MMSE score would indicate cognitive decline?
< 25
If patient has scored just below the normal threshold of MMSE due to sight impairment. What should be done?
Correct sight impairment and redo test, or perform other cognitive tests that do not require sight (Six-item Cognitive Impairment Test)
After MMSE is done to determine cognitive decline (<25), what investigation is best indicated?
CT scan (to see if there’s any degeneration of brain tissue, such as atrophy)
Lithium in pregnancy
- Cause of Ebstein anomaly
- in cases of severe bipolar disorder, benefits may outweigh the risks
- Lithium use during the first trimester of pregnancy has been reported to be associated with fetal cardiovascular
anomalies (e.g. Ebstein’s anomaly) and midfacial and other defects.
Risk of developing Ebstein’s anomaly on patients on lithium?
approximately 1 in 1000 to 2000
compared with 1 in 20000 in the general population.
If patient continues to use lithium during pregnancy, what should be investigated?
Ultrasound and echocardiogram at 16-20 weeks gestation to exclude foetal anomalies, especially cardiac anomalies
In relation to lithium dosage during pregnancy, what should be done in each trimester?
1st trimester: keep same dose as before pregnancy but heavily monitor foetus by US at 16-20 weeks.
2nd trimester: continue same lithium dosage.
3rd trimester: decrease lithium dosage by 25% to avoid floppy baby syndrome due to neonatal toxicity.
After delivery immediately increase lithium dosage due to
increased risk of relapse in postpartum period.
Sodium Valproate in pregnancy
1st trimester: decrease dose to prevent neural tube defects
2nd semester: continue decreased dosage through to 3rd semester
3rd trimester: increase the dosage to prevent seizures
If a patient, who has successfully been stable on prophylactic dose of a particular mood stabilizer, develops acute depression, what is the next best step in management?
- Adding an antidepressant to the prophylactic mood stabilizer: the choices of the drug would be the same as for major depression. SSRls first line.
- Increasing the dose of prophylactic mood stabilizer (ONLY if the patient’s psychosis is indicated in coming back, otherwise continue same dose)
List of anxiety disorders
- OCD
- GAD
List of personality disorder
Divided by Clusters:
-A
-B
-C
-Other
Cluster A personality disorder
- Paranoid Personality Disorder
- Schizoid Personality Disorder
- Schizotypal Personality Disorder
Cluster B personality disorder
- Antisocial Personality Disorder
- Borderline Personality Disorder
- Histrionic Personality Disorder
- Narcissistic Personality Disorder
Cluster C personality disorder
- Avoidant Personality Disorder
- Dependent Personality Disorder
- Obsessive-Compulsive Personality Disorder
Other personality disorders
Personality Change:
- Labile type
- Masochistic
- Disinhibited type
- Aggressive type
- Passive Aggressive type
- Apathetic type
- Combined type
- Unspecified type
List of eating disorders
- Anorexia Nervosa
- Bulimia Nervosa