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Year 4 Dermatology > Psoriasis > Flashcards

Psoriasis Flashcards

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Dermatology Board Prep flashcards
1
Q

What is psoriasis

A

chronic inflammatory dermatosis with epidermal hyperplasia

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2
Q

what terminology can be used to describe features of psoriasis under the microscope

A

acanthosis
parakeratosis
hyperkeratosis
absence of granular layer

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3
Q

what are Munro microabscesses

A

hallmark in psoriasis formed by neutrophils

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4
Q

what should you ask when taking a history

A 
triggers:
stress
diet 
infection 
drugs 
Koebner phenomenon - recent trauma
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5
Q

What sign can be seen on examination with removal of some of the scale

A

Auspitz sign

pinpoint bleeding upon removal of scale from dilated capillaries in dermal papillae

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6
Q

Where can you find psoriasis

A 
scalp 
nails 
Extensor regions 
Sacral 
Genital
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7
Q

What are the different types of psoriasis

A

chronic plaque psoriasis
palmoplantar pustular
guttate
erythrodermic

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8
Q

describe psoriatic lesions

A 
itch
flat raised lesions - plaques 
silvery scale 
underlying erythema 
well demarcated 
Auspitz sign 
symmetrical 
onycholysis 
nail pitting 
nail dystrophy 
subungal hyperkeratosis
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9
Q

Describe guttate psoriasis

A

acute onset
usually a history of previous infection - Strep throat
tear drop shaped lesions
widespread

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10
Q

what scoring system can be used in psoriasis

A

PASI

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11
Q

what co-morbidities may a patient with psoriasis also suffer

A 
Psoriatic arthritis (seronegative)
Heart disease 
Gout 
Metabolic syndrome 
Uveitis 
IBD
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12
Q

Management of psoriasis

A

Topical: emollients, steroids, Vit D analogues, coal tar, dithranol
Phototherapy
Systemic: MTX, ciclosporin, acitretin
Biological agents

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13
Q

triggers of psoriasis

A 
stress 
infection - strep throat 
drugs - lithium, B blockers, anti malarials, withdrawal of steroids
alcohol and smoking 
HIV/AIDS
Koebner phenomenon
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14
Q

list different types of psoriasis

A 
chronic plaque 
guttate 
palmoplantar 
palmoplantar pustulosis 
flexural 
scalp
erythrodermic 
Generalised pustular psoriasis
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15
Q

define erythroderma

A

> 90% of skin surface is red

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16
Q

side effects of phototherapy

A 
erythema 
blistering 
photoconjunctivitis 
reactivation of HSV 
photoageing 
photocarcinogenesis
17
Q

side effects of MTX

A 
hepatotoxicity 
pneumonitis 
bone marrow suppression 
teratogenicity 
reduced folic acid
18
Q

monitoring investigations for MTX

A

Baseline CXR
LFT
FBC
P3NP for liver fibrosis

19
Q

side effects of ciclosporin

A 
hypertension 
renal impairment (inevitable which is why patients can only be on it for max 6 months)
20
Q

monitoring for ciclosporin

A

FBC
LFT
cholesterol
eGFR

21
Q

side effects of acitretin

A

teratogenic
liver damage
high cholesterol

22
Q

monitoring for acitretin

A

FBC, U+E, LFT, cholesterol and triglycerides

also teratogenic

Year 4 Dermatology (16 decks)

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