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Year 4 Dermatology > Immunobullous disorders > Flashcards

Immunobullous disorders Flashcards

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Dermatology Board Prep flashcards
1
Q

what diseases come under the immunobullous disorders

A

bullous pemphigoid
pemphigus
dermatitis herpetiformis

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2
Q

what is the primary feature of bullous disorders

A

blistering

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3
Q

What is the most common type of pemphigus

A

pemphigus vulgaris

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4
Q

what is the pathology behind pemphigus

A

IgG antibodies attack desmoglein 3 withIN the epidermis superficially causing an intraepidermal blister and acantholysis

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5
Q

what is acantholysis

A

lysis of intercellular adhesion sites

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6
Q

features of pemphigus

A

superficial erosions
mucosal involvement
Fragile fluid filled flaccid blisters
Nikolsky sign positive

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7
Q

what is Nikolsky’s sign

A

rubbing of the bullae causes the skin to break away and peel

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8
Q

management of pemphigus

A

topical steroids and anaesthetics
PO steroids
immunosuppressants

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9
Q

what is the pathology behind bullous pemphigoid

A

IgG antibodies attack hemidesmosomes at the DEJ creating a DEEP SUBepidermal blister (no evidence of acantholysis)

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10
Q

investigations for bullous disorders

A

biopsy and immunofluorescence

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11
Q

features of bullous pemphigoid

A

itchy tense bullae, erythematous base
more common in elderly
Mucosal sparing
Niksolsky sign negative

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12
Q

Management of bullous pemphigoid

A

localised BP: high potent topical steroids
generalised:
tetracyclines
systemic steroids and immunosuppressants

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13
Q

what GI condition is associated with dermatitis herpetiformis

A

Coeliac disease

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14
Q

pathology behind dermatitis herpetiformis

A

granular IgA deposits in dermal papillae

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15
Q

features of dermatitis herpetiformis

A

itchy vesicles
symmetrical
elbows, knees, sacrum, buttocks, scapulae, face, scalp

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16
Q

hallmark of dermatitis herpetiformis

A

dermal microabscesses from PMN cells

17
Q

Management of dermatitis herpetiformis

A

gluten free diet

tetracyclines, dapsone!, sulphapyridine

18
Q

causes of blistering

A 
drugs - SJS
autoimmune 
trauma - burns
infection 
acute dermatitis 
metabolic 
genetic - Epidermolysis bullosa
19
Q

causes of intra epidermal blisters

A

pemphigus

HSV

20
Q

cause of sub corneal blister

A

bullous impetigo

21
Q

causes of sub epidermal blisters

A

bullous pemphigoid

dermatitis herpetiformis

22
Q

in an elderly patient who is complaining of pruritis and proceeds to form blisters, what is the diagnosis

A

bullous pemphigoid

23
Q

what age group does pemphigus affect

A

disease of middle age

24
Q

which is more common, bullous pemphigoid or pemphigus

A

bullous pemphigoid

Year 4 Dermatology (16 decks)

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