proton pump inhibitors

Question 1

Indications of proton pump inhibitors?

Answer 1

GORD, Zollinger-Ellison syndrome, gastric or duodenal ulcers, benign gastric ulcers, severe oesophagitis, acid related dyspepsia, maintenance therapy for peptic ulcers, eradication of Helicobacter pylori

Question 2

Contraindications of proton pump inhibitors?

Answer 2

none

Question 3

Mechanism of action of proton pump inhibitors?

Answer 3

inhibits gastric acid (HCl) secretion by blocking the proton pump (H, K-ATPase) enzyme system on the apical membrane of the gastric parietal cells - lowering overall stomach acid levels

Question 4

Side effects of proton pump inhibitors?

Answer 4

nausea, vomiting, diarrhoea, abdominal pain, constipation, flatulence, gastrointestinal disturbances, headache, dizziness

Question 5

Monitoring requirements for proton pump inhibitors?

Answer 5

measurement of serum-magnesium concentration should be considered before and during prolonged treatment with a proton pump inhibitor, especially if the patient is taking other drugs that can cause hypomagnesaemia

Question 6

Treatment cessation of proton pump inhibitors?

Answer 6

rebound acid secretion

Question 7

Patient and carer advice for proton pump inhibitors?

Answer 7

counselling on administration should be specifically advised and followed. don’t chew or crush capsule. children can only have omeprazole and lansoprazole. take 30 minutes before food