H1 receptor antagonist - antiemetics

Question 1

Indications of H1 receptor antagonists?

Answer 1

vertigo, labyrinthine disorders, motion/morning sickness, nausea, vomiting

Question 2

Contraindications of H1 receptor antagonists?

Answer 2

acute porphyria’s, neonate

Question 3

Mechanism of action of H1 receptor antagonists?

Answer 3

competitive antagonism of histamine - bind to H1 receptors therefore blocking the action of histamine in the vestibular and the vomiting centre, this helps prevent the initiation of vomiting

Question 4

Side effects of H1 receptor antagonists?

Answer 4

drowsiness, sedation

Question 5

Monitoring requirements of H1 receptor antagonists

Answer 5

none

Question 6

Treatment cessation of H1 receptor antagonists

Answer 6

none

Question 7

Patient and carer advice for H1 receptor antagonists

Answer 7

drowsiness can affect performance in driving and skilled tasks, sedating effects enhanced by alcohol