Protein Trafficking Flashcards

1
Q

What do free ribosomes synthesize?

A

Peripheral mmbrn proteins
Cytosolic proteins
Some proteins destined for nucleus, mitochondria, and peroxisomes

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2
Q

What does rER synthesize?

A

Mmbrn bound proteins + secretory proteins
Proteins in lysosomes, golgi and nuclear mmbrn

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3
Q

In the formation of rER, what is signal sequencing?

A

First 20-30 AAs tell ribosome to attach to ER

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4
Q

In the formation of rER, what is signal recognition particle (SRP)?

A

Binds signal and ribosome, then binds SRP receptor in ER

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5
Q

In the formation of rER, where is SRP receptor located and what does it do?

A

In ER, allows protein insertion into lumen of ER; creating rER

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