Protein Trafficking Flashcards
1
Q
What do free ribosomes synthesize?
A
Peripheral mmbrn proteins
Cytosolic proteins
Some proteins destined for nucleus, mitochondria, and peroxisomes
2
Q
What does rER synthesize?
A
Mmbrn bound proteins + secretory proteins
Proteins in lysosomes, golgi and nuclear mmbrn
3
Q
In the formation of rER, what is signal sequencing?
A
First 20-30 AAs tell ribosome to attach to ER
4
Q
In the formation of rER, what is signal recognition particle (SRP)?
A
Binds signal and ribosome, then binds SRP receptor in ER
5
Q
In the formation of rER, where is SRP receptor located and what does it do?
A
In ER, allows protein insertion into lumen of ER; creating rER