Enzyme Inhibition

Question 1

What are the 3 enzyme inhibitions?

Answer 1

Competitive, Non-competitive, Irreversible/Poisons

Question 2

What enzyme inhibition occurs in most enzymes?

Answer 2

Competitive

Question 3

What enzymes use non-competitive enzyme inhibition?

Answer 3

Allosteric enzymes + Hemoglobin

Question 4

What enzyme inhibitions are reversible?

Answer 4

Competitive + Non-competitive

Question 5

What enzyme inhibition is irreversible?

Answer 5

Irreversible/poisons

Question 6

In competitive enzyme inhibition, _____ binds at _____.

Answer 6

Competitor, ACTIVE site

Question 7

Competitive enzyme inhibition molecules _____ S, while Non-competitive enzyme inhibition molecules _____ S.

Answer 7

Look like
DO NOT look like

Question 8

What are the effects of competitive enzyme inhibition on Vmax? Km?

Answer 8

NO effect on Vmax
^ Km

Question 9

What are the effects of Non-competitive enzyme inhibition on Vmax? What are the kinetics explained by?

Answer 9

Decrease Vmax
Hill equation/plot

Question 10

Draw + label the Hill plot

Answer 10

Question 11

What are the irreversible/poisonous enzyme inhibition molecules?

Answer 11

Heavy metals (Silver + Mercury), Nerve gas, CO (carbon monoxide), CN (cyanide)