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Antimicrobials > Protein Synthesis Inhibitors > Flashcards

Protein Synthesis Inhibitors Flashcards

1
Q

30S inhibitors?

A

Aminoglycosides

Tetracyclines

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2
Q

50S inhibitors

A 
Chloramphenicol 
Clindamycin
Erythromycin (Macrolides)
Linezolid
Streptogramins
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3
Q

Aminoglycosides subclassification

A

Streptomycin
Gentamycin
Neonycin
Amikacin

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4
Q

Aminoglycosides spectrum and route?

A

Spectrum: aerobic gram -
Route: parenteral except neomycin (oral)

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5
Q

Aminoglycosides ADR?

A

Ototoxicity

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6
Q

Aminoglycosides contraindications

A

Pregnancy

Myasthenia gravis

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7
Q

Tetracyclines subclassification?

A

Short acting: oxytetracyclines, chlortetracyclines
Intermediate: methacycline
Long acting: doxycycline, minocycline

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8
Q

Tetracyclines spectrum and excretion?

A

Gram +
Gram -
Chlamydia, rickettsia, treponema
Renal clearance except long acting tetracyclines (bile)

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9
Q

Tetracyclines ADR?

A

Phototoxicity
Tooth enamel dysplasia
Dec bone growth in kids
Liver dysfunction in pregnancy

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10
Q

Aminoglycosides and tetracyclines MOA?

A

Aminoglycosides: misreading
Tetracyclines: inhibit mRNA binding with tRNA

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11
Q

Chloramphenicol MOA?

A

Inhibits transpeptidation

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12
Q

Chloramphenicol ADRs?

A

Gray baby syndrome

Aplastic anemia

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13
Q

Macrolides MOA?

A

Inhibits translocation

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14
Q

Macrolides subclassification

A

Erythromycin
Azithromycin
Clarithromycin

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15
Q

Macrolides ADR?

A

Reversible deafness

Arrhythmias (inc QT interval)

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16
Q

Excretion of chloramphenicol and macrolides via?

A

Bile

17
Q

Which 50s inhibitor(s) inhibit cyt p450 system?

A

Chloramphenicol and Macrolides

18
Q

Clindamycin MOA?

A

Inhibits translocation

19
Q

Clindamycin ADR?

A

Pseudomembranous colitis

20
Q

Streptogramins subclassification and route

A

Quinuprisin and dalfoprisin

Parenteral

21
Q

Linezolid MOA

A

inhibits initiation complex formation

22
Q

Linezolid ADR

A

Bone marrow suppression

Serotonin syndrome

23
Q

50 inhibitors spectrum

A 
Chloramphenicol; broad 
Macrolides; wide
Clindamycin; narrow
Streptogramins; gram + cocci, VRSA
Linezolid: VRSA, VRE Etc
24
Q

All 50 inhibitors have oral route except _______

A

Streptogramins

Antimicrobials (9 decks)

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