Protein Synthesis Inhibitors

Question 1

30S inhibitors?

Answer 1

Aminoglycosides

Tetracyclines

Question 2

50S inhibitors

Answer 2

Chloramphenicol 
Clindamycin
Erythromycin (Macrolides)
Linezolid
Streptogramins

Question 3

Aminoglycosides subclassification

Answer 3

Streptomycin
Gentamycin
Neonycin
Amikacin

Question 4

Aminoglycosides spectrum and route?

Answer 4

Spectrum: aerobic gram -
Route: parenteral except neomycin (oral)

Question 5

Aminoglycosides ADR?

Answer 5

Ototoxicity

Question 6

Aminoglycosides contraindications

Answer 6

Pregnancy

Myasthenia gravis

Question 7

Tetracyclines subclassification?

Answer 7

Short acting: oxytetracyclines, chlortetracyclines
Intermediate: methacycline
Long acting: doxycycline, minocycline

Question 8

Tetracyclines spectrum and excretion?

Answer 8

Gram +
Gram -
Chlamydia, rickettsia, treponema
Renal clearance except long acting tetracyclines (bile)

Question 9

Tetracyclines ADR?

Answer 9

Phototoxicity
Tooth enamel dysplasia
Dec bone growth in kids
Liver dysfunction in pregnancy

Question 10

Aminoglycosides and tetracyclines MOA?

Answer 10

Aminoglycosides: misreading
Tetracyclines: inhibit mRNA binding with tRNA

Question 11

Chloramphenicol MOA?

Answer 11

Inhibits transpeptidation

Question 12

Chloramphenicol ADRs?

Answer 12

Gray baby syndrome

Aplastic anemia

Question 13

Macrolides MOA?

Answer 13

Inhibits translocation

Question 14

Macrolides subclassification

Answer 14

Erythromycin
Azithromycin
Clarithromycin

Question 15

Macrolides ADR?

Answer 15

Reversible deafness

Arrhythmias (inc QT interval)

Question 16

Excretion of chloramphenicol and macrolides via?

Answer 16

Bile

Question 17

Which 50s inhibitor(s) inhibit cyt p450 system?

Answer 17

Chloramphenicol and Macrolides

Question 18

Clindamycin MOA?

Answer 18

Inhibits translocation

Question 19

Clindamycin ADR?

Answer 19

Pseudomembranous colitis

Question 20

Streptogramins subclassification and route

Answer 20

Quinuprisin and dalfoprisin

Parenteral

Question 21

Linezolid MOA

Answer 21

inhibits initiation complex formation

Question 22

Linezolid ADR

Answer 22

Bone marrow suppression

Serotonin syndrome

Question 23

50 inhibitors spectrum

Answer 23

Chloramphenicol; broad 
Macrolides; wide
Clindamycin; narrow
Streptogramins; gram + cocci, VRSA
Linezolid: VRSA, VRE Etc

Question 24

All 50 inhibitors have oral route except _______

Answer 24

Streptogramins