Folic Acid Synthesis Inhibitors

Question 1

Classification:

Answer 1

Sulfonamides

Diaminopyrimidines: Trimethoprim, pyrimethamine

Question 2

Sulfonamides MOA?

Answer 2

inhibits dihydropteroate synthase

Question 3

Trimethoprim (TMP) MOA?

Answer 3

Inhibits dihydrofolate reductase

Question 4

Sulfonamides (smx) forms?

Answer 4

Many forms

Oral, topical etc

Question 5

Silver sulfadiazine is used for _________

Answer 5

Infective burns

Question 6

Sulfadizaine + pyrimethamine is used for _______

Answer 6

Toxoplasmosis in HIV patients

Question 7

SMX spectrum

Answer 7

Gram +
Gram -
Nocardia etc

Question 8

SMX can cross BBB.

T or F

Answer 8

TRUE

Question 9

SMX is also used to treat _______

Answer 9

IBS

Question 10

SMX ADRs?

Answer 10

Steven johnson syndrome
Hemolysis in G6PD def patients
Photosensitivity
Kernicterus

Question 11

SMX Interactions?

Answer 11

Aspirin -> nephrotoxicity

Displaces other substances bound to albumin like warfarin, bilirubin, sulfonyl urea etc

Question 12

SMX Contraindications

Answer 12

Preggo

Kids

Question 13

TMP ADRs?

Answer 13

Pancytopenia

Hyperkalemia

Question 14

Pancytopenia caused by TMP can be overcome by ___________

Answer 14

Leucovorin

Question 15

TMP-SMX together is known as _______

Answer 15

Bactrim

Question 16

Bactrim is mostly used for

Answer 16

UTIs and pneumocystis pneumonia in HIV pt.