Anti Helminthics Flashcards
Anti-helminthics MOAs?
NM paralysis of worm
Ca and Cl entry
Metabolism
Microtubular formation
Classification
Tape worm: praziquantel
Whipworm: albendazole and mebendazole
Roundworm, hookworm, pinworm: albendazole
Mebendazole, levamisole
Mebendazole MOA?
Inhibits B-tubulin which inhibits actin myosin filaments of the worm
Mebendazole spectrum
Broad
Intestinal nematodes + cestodes
Mebendazole is taken with ______ + reason
Purgative bc expulsion process is slow
Mebendazole ADRs?
Hepatotoxic
Worms in nose and mouth
Mebendazole contraindicated in?
Early pregnancy
< 2y/o
Hepatic or renal patient
Praziquantel MOA?
Inc Ca++ permeability of parasite cell
Praziquantel ADRs?
Fever
Lethargy
Diarrhea
Abd pain
Pyrantel pamoate MOA?
Depolarise NM junctions
Pyrantel pamoate Spectrum?
Nematodes infection
Pyrantel pamoate ADR
Rash
GI upset
Headache
Diethylcarmazine is drug of choice for _____
Filiarisis
Diethylcarbamazine MOA?
Inc phagocytosis
Diethylcarbamazine and ivermectin ADR?
Mazzotti rxn
Ivermection MOA?
Alters Cl- permeability causing paralysis
Ivermectin is a ________
GABA agonist
Ivermectin spectrum
Scabies
Intestinal nematodes
Filiarisis
Levamisole MOA
Stimulates ganglia which causes tonic paralysis and separates its hooks
Levamisole Spectrum
Ascaris and akylostoma
Levamisole ADRs?
Nausea
Drowsiness/insomnia
Abd pain
Fatigue
Piperazine MOA
NM paralysis
Piperazine spectrum
Ascaris
Enterobius
Piperazine is not taken with a purgative
True or False
False
Piperazine ADRs
Urticaria
Convulsions
Resp failure
Which anti helminthic is safe for pregnancy?
Piperazine
