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Antimicrobials > Anti malarial > Flashcards

Anti malarial Flashcards

1
Q

Classification

A

Tissue schizonticides; primaquine
Blood schizonticides; cholorquine, quinine
Sporontocide; pyrimethamine, proguanil

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2
Q

Primaquine is a __________

A

Tissue schizonticide

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3
Q

Primaquine MOA?

A

Interferes w mitochondrial activity

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4
Q

Primaquine kills schizonts as well as _______

A

Hypnozoites (liver form)

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5
Q

Primaquine is used to eradicate?

A

P vivax and ovale

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6
Q

_______ is gametocidal for all 4 species

A

Primaquine

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7
Q

Primaquine ADRs

A

Leukopenia
Agranulocytosis
Leukocytosis
Arrythmias
Hemolysis
Methemoglobinemia

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8
Q

Contraindication of primaquine

A

G6PD def
Pregnancy

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9
Q

Chloroquine is a ________ base

A

Weak base

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10
Q

Chloroquine MOA?

A

Blocks plasmodiums heme polymerase

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11
Q

Chloroquine only kills which form

A

Erythrocytic form

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12
Q

Chloroquine ADRs?

A

Retinopathy -> blindess
Auditory impairment
Peripheral neuropathy
Pulmonary edema
Convulsions

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13
Q

Chloroquine also used for ____

A

Amebic liver abscess

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14
Q

Quinine is an ________

A

Alkaloid

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15
Q

Quinine is given in _______

A

Chloroquine resistance

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16
Q

Quinine ADRs?

A

Cinchonism
Hypotension
Neurological symptoms

17
Q

Sporontocides ROUTE and MOA?

A

Oral
Inhibit plasmodias dihydrofolate Reductase enz

18
Q

Sporontocides ADRs?

A

Itching
Rashes
Mouth ulcers
Alopecia

19
Q

Which anti malarial drug is safe for pregnancy?

A

Sporontocides (pyrimethamine and proguanil)
But taken w standard dosage of folate supplements

20
Q

Drugs used for severe/cerebral malaria?
And their ROUTE

A

Artesunate
Quinidine
IV ROUTE

21
Q

Malaria prophylaxis?

A

Chloroquine 1wk before entering endemic area
Continued during stay
For 4 wks after leaving
Primaquine also taken for 14 days

Antimicrobials (9 decks)

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