Anti malarial Flashcards
Classification
Tissue schizonticides; primaquine
Blood schizonticides; cholorquine, quinine
Sporontocide; pyrimethamine, proguanil
Primaquine is a __________
Tissue schizonticide
Primaquine MOA?
Interferes w mitochondrial activity
Primaquine kills schizonts as well as _______
Hypnozoites (liver form)
Primaquine is used to eradicate?
P vivax and ovale
_______ is gametocidal for all 4 species
Primaquine
Primaquine ADRs
Leukopenia
Agranulocytosis
Leukocytosis
Arrythmias
Hemolysis
Methemoglobinemia
Contraindication of primaquine
G6PD def
Pregnancy
Chloroquine is a ________ base
Weak base
Chloroquine MOA?
Blocks plasmodiums heme polymerase
Chloroquine only kills which form
Erythrocytic form
Chloroquine ADRs?
Retinopathy -> blindess
Auditory impairment
Peripheral neuropathy
Pulmonary edema
Convulsions
Chloroquine also used for ____
Amebic liver abscess
Quinine is an ________
Alkaloid
Quinine is given in _______
Chloroquine resistance
Quinine ADRs?
Cinchonism
Hypotension
Neurological symptoms
Sporontocides ROUTE and MOA?
Oral
Inhibit plasmodias dihydrofolate Reductase enz
Sporontocides ADRs?
Itching
Rashes
Mouth ulcers
Alopecia
Which anti malarial drug is safe for pregnancy?
Sporontocides (pyrimethamine and proguanil)
But taken w standard dosage of folate supplements
Drugs used for severe/cerebral malaria?
And their ROUTE
Artesunate
Quinidine
IV ROUTE
Malaria prophylaxis?
Chloroquine 1wk before entering endemic area
Continued during stay
For 4 wks after leaving
Primaquine also taken for 14 days
