Antifungals

Question 1

Antifungals for drastic systemic infections?

Answer 1

AMPHOTERICIN B
FLUOCYTOCINE
AZOLES
ECHINOCANDINS

Question 2

Antifungals for mucocutaneous/mild systemic infections?

Answer 2

Griseofulvin

Question 3

Cutaneous fungal infection antifungal?

Answer 3

Nystatin

Question 4

AMPHOTERICIN B MOA?

Answer 4

Interacts with ergosterol causing pores in membrane and cell death

Question 5

Route of AMPHOTERICIN B

Answer 5

IV

Intrathecal slow infusion

Question 6

AMPHOTERICIN B ADRs?

Answer 6

Nephrotoxicity 
Renal tubular acidosis
Arrythmias
Anemia
Phlebitis

Question 7

AMPHOTERICIN B nephrotoxicity can be avoided by ______

Answer 7

Liposomal AMPHOTERICIN B

Question 8

NYSTATIN MOA?

Answer 8

Same as amphotericin b

Question 9

Nystatin Route?

Answer 9

TOPICAL

Question 10

Nystatin clinical use?

Answer 10

Candida

Diaper rash

Question 11

Fluocytocine MOA?

Answer 11

Converted to 5fluorouracil which affects DNA n RNA synthesis

Question 12

FLUOCYTOCINE Clinical uses?

Answer 12

Opportunistic inf

Cryptococcal meningitis

Question 13

FLUOCYTOCINE ADRs?

Answer 13

Bone marrow suppression

Question 14

AZOLES subclassification

Answer 14

Triazole

Imidazole

Question 15

Azoles MOA?

Answer 15

Inhibit cyt p450 sys which inhibits ergosterol syn

Question 16

Which antifungal is contraindicated in pregnancy?

Answer 16

Azoles

Griseofulvin

Question 17

Azoles ADRs?

Answer 17

Suppresses testosterone-> gynecomastia

Menstrual irregularities

Question 18

Ketoconazole is used for the treatment of ___________ as well

Answer 18

Cushing’s

Question 19

Griseofulvin MOA?

Answer 19

Inhibits microtubule formation

Question 20

griseofulvin clinical uses

Answer 20

Oral therapy for skin or nail inf

Question 21

Griseofulvin ADR?

Answer 21

Teratogenic
Induces cyt p450 sys
Porphyria attacks
Carcinogenic