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Antimicrobials > Anti-TB > Flashcards

Anti-TB Flashcards

1
Q

1st line of ATT

A 
Rifampin
Isoniazid 
Pyrizinamide
Ethambutol
Dapsone
Streptomycin
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2
Q

2nd line of ATT?

A

Kanamycin n amikacin
Cycloserine
Capreomycin
PAS

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3
Q

Why is 2nd line of ATT Not preferred?

A

More toxic

Less effective

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4
Q

ATT REGIME for latent TB?

A

INH x6-9montha

Rifampin x4months

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5
Q

ATT REGIME FOR ACTIVE TB?

A

RIPE - 2 months
Rifampin + INH - 4months
B6 supplements
+ streptomycin if it becomes miliary

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6
Q

For MYCOBACTERIUM LEPRAE?

A

Dapsone

Rifampin

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7
Q

Rifampin MOA?

A

Inhibits RNA polymerase

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8
Q

Rifampin ADR?

A

Red urine

Cyt p450 inducer

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9
Q

INH can cross BBB and placenta

T OR F

A

True

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10
Q

INH ADRs?

A

Anion gap metabolic acidosis
B6 deficiency (anemia and neuropathy)
Hemolysis in G6PD
Seizures

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11
Q

INH MOA?

A

Activated by catalase peroxidase
Inhibits enoyl reductase
Which inhibits mycolic acid synthesis

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12
Q

Pyrizinamide MOA?

A

Unknown

Maybe FA SYNTHASE inhibition

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13
Q

Pyrizinamide ADR?

A

Hyperuricemia/gout

Athralgia

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14
Q

Ethambutol MOA?

A

Inhibits arabinosoyl trasnferase which inhibits arabinogalactin formation (cell wall component)

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15
Q

Ethambutol ADR?

A

Optic neuritis

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16
Q

Ethambutol is _______ stable

A

Heat

17
Q

Dapsone MOA?

A

Inhibits formation of DHF from PABA

18
Q

Dapsone ADR?

A

Methemoglobinemia

Hemolysis in G6PD deficiency pt.

19
Q

Streptomycin MOA?

A

Its a 30S inhibitor

20
Q

Streptomycin ADR?

A

Ototoxicity

21
Q

Streptomycin contraindicated in?

A

Mysathenia gravis

22
Q

______ is used instead of rifampin in HIV + patients

A

Rifabutin

Antimicrobials (9 decks)

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