DNA Gyrase Inhibitors

Question 1

Quinolones MOA?

Answer 1

Inhibits topoisomerase II and IV

Question 2

Quinolones absorption is disrupted by _______

Answer 2

Antacids

Question 3

Classification of quinolones

Answer 3

1st gen: nalidixic acid
2nd gen: ciprofloxacin
3rd gen: levofloxacin
4th gen: trovafloxacin

Question 4

Quinolones spectrum?

Answer 4

1st gen: mostly gram - except pseudomonas
2nd gen: gram -, pseudomonas, some gram +, some atypicals
3rd gen: same as 2nd gen with extended gram + and atypical coverage
4th gen: same as 3rd gen with broad anaerobe coverage

Question 5

QUINOLONES ADR?

Answer 5

Tendonitis /arthropathy
Arrhythmia (inc Q-T int; torsades de pointes)
Liver toxicity

Question 6

QUINOLONES CONTRAINDICATIONS

Answer 6

preggo women
Lactating women
<18 y/o

Question 7

Quinolones uses?

Answer 7

UTIs
GI infections
Swimmers ears