Cell Wall Synthesis Inhibitors

Question 1

B lactam cell wall synthesis inhibitors

Answer 1

Penicillin
Cephalosporins
Carbapenems
Monobactems

Question 2

Non B Lactam Cell wall synthesis inhibitors

Answer 2

Vancomycin
Fosfomycin
Cycloserine
Bacitracin

Question 3

Penicillin classification

Answer 3

Natural / Narrow spectrum
Synthetic/aminopenicillins/ broad spectrum
Anti staphylococcal/ very narrow spectrum
Anti pseudomonal/ extended spectrum

Question 4

Natural pencillin

Answer 4

Penicillin G
Pencillin V

Question 5

Aminopenicillin

Answer 5

Amoxicillin
Ampicillin

Question 6

Antistaphylococcal penicillin

Answer 6

Nafcillin
Oxacillin

Question 7

Antipseudomonal pencillin

Answer 7

Piperacillin

Question 8

ADR of All types of pencillins

Answer 8

Natural: direct coombs + hemolytic
Semi-Synthetic: pseudomembranous colitis
Anti staphylococcal: interstitial nephritis
Antipseudomonal: hypersensitivity

Question 9

Spectrum of all types of penicillins

Answer 9

Natural: gram+, gram- cocci, spirochetes
Semi-synthetic: gram+,gram-,spirochetes
Anti staphylococcal: S.areus
Antipseudomonal: pseudomonas, gram- rods

Question 10

Which penicillin is B lactam resistant?

Answer 10

Anti staphylococcal pencillins

Question 11

B lactamase inhibitors (any 3)

Answer 11

Clavulanic acud
Sulbactum
Tazobactam

Question 12

______________ pencillin are excreted via bile rest via kidney

Answer 12

Nafcillin and oxacillin

Question 13

First gen cephalosporins

Answer 13

Cefazolin
Cephalexin

Question 14

Second gen cephalosporins

Answer 14

Cefactor
Cefuroxime

Question 15

Third gen cephalosporins

Answer 15

Ceftriaxone
Cefixime
Cefdinir

Question 16

Fourth gen cephalosporins

Answer 16

Cefepime

Question 17

Difference between all gens of cephalosporins

Answer 17

1 and 2 gen cant cross BBB (except cefuroxime from 2nd gen)
First gen spectrum: gram + cocci, PEcK
Second gen spectrum: more gram - , anaerobes
Third gen spectrum: gram + and - cocci, gram - rods
Fourth gen: wider spectrum

Question 18

All cephalosporins have renal clearance except ____________

Answer 18

Ceftriaxone

Question 19

All cephalosporins are parenteral route except ______, _________ and _________.

Answer 19

Cefdinir
Cefixime
Cephalexin

Question 20

Carbapenems (2)

Answer 20

Imipenems
Meropenems

Question 21

Meropenems are more preferred because
(Three reasons)

Answer 21

1. Imipenems deactivated by dehydropeptidases
2. Meropenems more active against anaerobes
3. Dec risk of seizures

Question 22

Cephalosporins ADR

Answer 22

vitamin K deficiency
Autoimmune hemolytic anemia

Question 23

Carbapenems and monobactems are not B lacatamase resistant: TRUE OR FALSE

Answer 23

FALSE

Question 24

Vacomycin Spectrum

Answer 24

MRSA
S epidermidis
Enterococcus
Clostridium deficile

Question 25

Vancomycin ADR?

Answer 25

Vancomycin infusion/ Red man syndrome rxn:
Nephrotoxicity
Ototoxicity
Thrombophlebitis

Question 26

Carbapenems ADR

Answer 26

Seizures

Question 27

Monobactems

Answer 27

Aztreonam
Used for patients with penicillin allergy and renal insufficiency

Question 28

Which cell wall synthesis inhibitor is safe for pregnancy?

Answer 28

Fosfomycin

Question 29

Bacitracin is highly __________

Answer 29

Nephrotoxic