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Antimicrobials > Cell Wall Synthesis Inhibitors > Flashcards

Cell Wall Synthesis Inhibitors Flashcards

1
Q

B lactam cell wall synthesis inhibitors

A

Penicillin
Cephalosporins
Carbapenems
Monobactems

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2
Q

Non B Lactam Cell wall synthesis inhibitors

A

Vancomycin
Fosfomycin
Cycloserine
Bacitracin

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3
Q

Penicillin classification

A

Natural / Narrow spectrum
Synthetic/aminopenicillins/ broad spectrum
Anti staphylococcal/ very narrow spectrum
Anti pseudomonal/ extended spectrum

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4
Q

Natural pencillin

A

Penicillin G
Pencillin V

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5
Q

Aminopenicillin

A

Amoxicillin
Ampicillin

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6
Q

Antistaphylococcal penicillin

A

Nafcillin
Oxacillin

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7
Q

Antipseudomonal pencillin

A

Piperacillin

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8
Q

ADR of All types of pencillins

A

Natural: direct coombs + hemolytic
Semi-Synthetic: pseudomembranous colitis
Anti staphylococcal: interstitial nephritis
Antipseudomonal: hypersensitivity

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9
Q

Spectrum of all types of penicillins

A

Natural: gram+, gram- cocci, spirochetes
Semi-synthetic: gram+,gram-,spirochetes
Anti staphylococcal: S.areus
Antipseudomonal: pseudomonas, gram- rods

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10
Q

Which penicillin is B lactam resistant?

A

Anti staphylococcal pencillins

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11
Q

B lactamase inhibitors (any 3)

A

Clavulanic acud
Sulbactum
Tazobactam

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12
Q

______________ pencillin are excreted via bile rest via kidney

A

Nafcillin and oxacillin

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13
Q

First gen cephalosporins

A

Cefazolin
Cephalexin

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14
Q

Second gen cephalosporins

A

Cefactor
Cefuroxime

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15
Q

Third gen cephalosporins

A

Ceftriaxone
Cefixime
Cefdinir

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16
Q

Fourth gen cephalosporins

A

Cefepime

17
Q

Difference between all gens of cephalosporins

A

1 and 2 gen cant cross BBB (except cefuroxime from 2nd gen)
First gen spectrum: gram + cocci, PEcK
Second gen spectrum: more gram - , anaerobes
Third gen spectrum: gram + and - cocci, gram - rods
Fourth gen: wider spectrum

18
Q

All cephalosporins have renal clearance except ____________

A

Ceftriaxone

19
Q

All cephalosporins are parenteral route except ______, _________ and _________.

A

Cefdinir
Cefixime
Cephalexin

20
Q

Carbapenems (2)

A

Imipenems
Meropenems

21
Q

Meropenems are more preferred because
(Three reasons)

A
  1. Imipenems deactivated by dehydropeptidases
  2. Meropenems more active against anaerobes
  3. Dec risk of seizures
22
Q

Cephalosporins ADR

A

vitamin K deficiency
Autoimmune hemolytic anemia

23
Q

Carbapenems and monobactems are not B lacatamase resistant: TRUE OR FALSE

A

FALSE

24
Q

Vacomycin Spectrum

A

MRSA
S epidermidis
Enterococcus
Clostridium deficile

25
Q

Vancomycin ADR?

A

Vancomycin infusion/ Red man syndrome rxn:
Nephrotoxicity
Ototoxicity
Thrombophlebitis

26
Q

Carbapenems ADR

A

Seizures

27
Q

Monobactems

A

Aztreonam
Used for patients with penicillin allergy and renal insufficiency

28
Q

Which cell wall synthesis inhibitor is safe for pregnancy?

A

Fosfomycin

29
Q

Bacitracin is highly __________

A

Nephrotoxic

Antimicrobials (9 decks)

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