Protein Formulations 2

Question 1

How can implants be delivered?

Answer 1

Through intra muscular or subcutaneous route

Question 2

What are the 5 types of implantable systems?

Answer 2

Polymer gel matrix 
Polymer fibre systems 
Osmotic mini pumps 
Tablet type implants 
Automatic feedback system

Question 3

How to improve oral bioavailability of peptides?

Answer 3

Peptidase inhibitor

Saturation/bypassing of intestinal peptidases

Penetration enhancers

Reduction of hepatic first pass clearance

Non passive and par acellular transport

Question 4

Why use inhalation delivery of insulin?

Answer 4

If insulin SC fails to mimic endogenous insulin

Compliance of injections

Complications of retinopathy, neuropathy and nephropathy

Question 5

What are the pharmacokinetics/ dynamic benefits of insulin?

Answer 5

Serum conc peak earlier and decay more rapidly

Onset of action quicker and duration prolonged

Question 6

What are the problems with parenteral routes?

Answer 6

Repeated admin
Patient compliance
Stability of dosage form